Analysis of 8q24.21 miRNA cluster expression and copy number variation in gastric cancer

被引：15

作者：

Anauate, Ana C. ^{[1
]}

Leal, Mariana F. ^{[1
]}

Wisnieski, Fernanda ^{[1
,2
]}

Santos, Leonardo C. ^{[1
]}

Gigek, Carolina O. ^{[1
,3
]}

Chen, Elizabeth S. ^{[1
]}

Calcagno, Danielle Q. ^{[4
]}

Assumpcao, Paulo P. ^{[4
]}

Demachki, Samia ^{[4
]}

Arasaki, Carlos H. ^{[3
]}

Artigiani, Ricardo ^{[5
]}

Rasmussen, Lucas T. ^{[6
]}

Payao, Spencer M. ^{[6
]}

Burbano, Rommel R. ^{[4
,7
,8
]}

Smith, Marilia A. C. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Morfol & Genet, Disciplina Genet, BR-04023900 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Dept Med, Disciplina Gastroenterol, BR-04040002 Sao Paulo, Brazil

[3] Univ Fed Sao Paulo, Dept Cirurgia, Disciplina Gastroenterol Cirug, BR-04024002 Sao Paulo, Brazil

[4] Univ Fed Para, Hosp Univ Joao de Barros Barreto, Nucleo Pesquisas Oncol, BR-66073000 Belem, Para, Brazil

[5] Univ Fed Sao Paulo, Dept Patol, BR-04023062 Sao Paulo, Brazil

[6] Fac Med Marilia, Dept Genet & Biol Mol, BR-17519050 Marilia, Brazil

[7] Univ Fed Para, Inst Ciencias Biol, Lab Citogenet Humana, BR-66075110 Belem, Para, Brazil

[8] Hosp Ophir Loyola, Lab Biol Mol, BR-66063240 Belem, Para, Brazil

来源：

FUTURE MEDICINAL CHEMISTRY | 2019年 / 11卷 / 09期

基金：

巴西圣保罗研究基金会;

关键词：

8q24; CNV; gastric cancer; gene expression; miRNA; miR-1204; miR-1205; miR-1206; miR-1207; miR-1208; CONVENTIONAL CYTOGENETIC CHARACTERIZATION; C-MYC AMPLIFICATION; NORTHERN BRAZIL; PROGNOSTIC BIOMARKERS; NUMERICAL ABERRATIONS; INDIVIDUALS; MICRORNAS; CHROMOSOME-8; DIFFUSE; INTERRELATIONSHIP;

D O I：

10.4155/fmc-2018-0477

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aim: To analyze gene expression and copy number of five miRNAs (miR-1204, miR-1205, miR-1206, miR-1207 and miR-1208) localized in this chromosome region in gastric cancer (GC). Materials& methods: 65 paired neoplastic and non-neoplastic specimens collected from GC patients and 20 non-neoplastic gastric tissues from cancer-free individuals were included in this study. The expression levels of the five miRNAs were accessed by real time qPCR and were correlated. Results: MiR-1207-3p, miR-1205, miR-1207-5p and miR-1208 were upregulated in approximately 50% of GC tumors in relation to those of adjacent non-neoplastic tissues. MiR-1205 expression was associated with gain of gene copies and was upregulated in adjacent non-neoplastic samples relative to external controls. Conclusion: The coexpression of the 8q24 miRNAs indicated the role of miR-1205 in the initiation of gastric cancer development.

引用

页码：947 / 958

页数：12

共 50 条

[21] MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review [J].

Iorio, Marilena V. ;

Croce, Carlo M. .

EMBO MOLECULAR MEDICINE, 2012, 4 (03) :143-159

[22] Mechanisms of MicroRNA Deregulation and MicroRNA Targets in Gastric Cancer [J].

Irmak-Yazicioglu, M. Burcu .

ONCOLOGY RESEARCH AND TREATMENT, 2016, 39 (03) :136-139

[23] 2 HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA - DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA - AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION [J].

LAUREN, P .

ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA, 1965, 64 (01) :31-&

[24] MYC, TP53, and Chromosome 17 Copy-Number Alterations in Multiple Gastric Cancer Cell Lines and in Their Parental Primary Tumors [J].

Leal, Mariana Ferreira ;

Calcagno, Danielle Queiroz ;

Ferreira Borges da Costa, Joana de Fatima ;

Raiol Silva, Tanielly Cristina ;

Khayat, Andre Salim ;

Chen, Elizabeth Suchi ;

Assumpcao, Paulo Pimentel ;

Cardoso Smith, Marilia de Arruda ;

Burbano, Rommel Rodriguez .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011,

[25] Establishment and conventional cytogenetic characterization of three gastric cancer cell lines [J].

Leal, Mariana Ferreira ;

Martins do Nascimento, Jose Luiz ;

Araujo da Silva, Carla Elvira ;

Vita Lamarao, Maria Fernanda ;

Calcagno, Danielle Queiroz ;

Khayat, Andre Salim ;

Assumpcao, Paulo Pimentel ;

Cabral, Isabel Rosa ;

Cardoso Smith, Marilia de Arruda ;

Burbano, Rommel Rodriguez .

CANCER GENETICS AND CYTOGENETICS, 2009, 195 (01) :85-91

[26] Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors [J].

Lee, Eun Joo ;

Baek, Myungwon ;

Gusev, Yuriy ;

Brackett, Daniel J. ;

Nuovo, Gerard J. ;

Schmittgen, Thomas D. .

RNA, 2008, 14 (01) :35-42

[27] Conventional cytogenetic characterization of a new cell line, ACP01, established from a primary human gastric tumor [J].

Lima, EM ;

Rissino, JD ;

Harada, ML ;

Assumpçäo, PP ;

Demachki, S ;

Guimaräes, AC ;

Casartelli, C ;

Smith, MAC ;

Burbano, RR .

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2004, 37 (12) :1831-1838

[28] Epigenetic Regulation of microRNAs in Gastric Cancer [J].

Ma, Jiaojiao ;

Hong, Liu ;

Chen, Zheng ;

Nie, Yongzhan ;

Fan, Daiming .

DIGESTIVE DISEASES AND SCIENCES, 2014, 59 (04) :716-723

[29] Genetics of gastric cancer [J].

McLean, Main I. H. ;

El-Omar, Emad M. .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2014, 11 (11) :664-674

[30] Cancer epigenetics: Moving forward [J].

Nebbioso, Angela ;

Tambaro, Francesco Paolo ;

Dell'Aversana, Carmela ;

Altucci, Lucia .

PLOS GENETICS, 2018, 14 (06)

← 1 2 3 4 5 →