Analysis of 8q24.21 miRNA cluster expression and copy number variation in gastric cancer

被引：15

作者：

Anauate, Ana C. ^{[1
]}

Leal, Mariana F. ^{[1
]}

Wisnieski, Fernanda ^{[1
,2
]}

Santos, Leonardo C. ^{[1
]}

Gigek, Carolina O. ^{[1
,3
]}

Chen, Elizabeth S. ^{[1
]}

Calcagno, Danielle Q. ^{[4
]}

Assumpcao, Paulo P. ^{[4
]}

Demachki, Samia ^{[4
]}

Arasaki, Carlos H. ^{[3
]}

Artigiani, Ricardo ^{[5
]}

Rasmussen, Lucas T. ^{[6
]}

Payao, Spencer M. ^{[6
]}

Burbano, Rommel R. ^{[4
,7
,8
]}

Smith, Marilia A. C. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Morfol & Genet, Disciplina Genet, BR-04023900 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Dept Med, Disciplina Gastroenterol, BR-04040002 Sao Paulo, Brazil

[3] Univ Fed Sao Paulo, Dept Cirurgia, Disciplina Gastroenterol Cirug, BR-04024002 Sao Paulo, Brazil

[4] Univ Fed Para, Hosp Univ Joao de Barros Barreto, Nucleo Pesquisas Oncol, BR-66073000 Belem, Para, Brazil

[5] Univ Fed Sao Paulo, Dept Patol, BR-04023062 Sao Paulo, Brazil

[6] Fac Med Marilia, Dept Genet & Biol Mol, BR-17519050 Marilia, Brazil

[7] Univ Fed Para, Inst Ciencias Biol, Lab Citogenet Humana, BR-66075110 Belem, Para, Brazil

[8] Hosp Ophir Loyola, Lab Biol Mol, BR-66063240 Belem, Para, Brazil

来源：

FUTURE MEDICINAL CHEMISTRY | 2019年 / 11卷 / 09期

基金：

巴西圣保罗研究基金会;

关键词：

8q24; CNV; gastric cancer; gene expression; miRNA; miR-1204; miR-1205; miR-1206; miR-1207; miR-1208; CONVENTIONAL CYTOGENETIC CHARACTERIZATION; C-MYC AMPLIFICATION; NORTHERN BRAZIL; PROGNOSTIC BIOMARKERS; NUMERICAL ABERRATIONS; INDIVIDUALS; MICRORNAS; CHROMOSOME-8; DIFFUSE; INTERRELATIONSHIP;

D O I：

10.4155/fmc-2018-0477

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aim: To analyze gene expression and copy number of five miRNAs (miR-1204, miR-1205, miR-1206, miR-1207 and miR-1208) localized in this chromosome region in gastric cancer (GC). Materials& methods: 65 paired neoplastic and non-neoplastic specimens collected from GC patients and 20 non-neoplastic gastric tissues from cancer-free individuals were included in this study. The expression levels of the five miRNAs were accessed by real time qPCR and were correlated. Results: MiR-1207-3p, miR-1205, miR-1207-5p and miR-1208 were upregulated in approximately 50% of GC tumors in relation to those of adjacent non-neoplastic tissues. MiR-1205 expression was associated with gain of gene copies and was upregulated in adjacent non-neoplastic samples relative to external controls. Conclusion: The coexpression of the 8q24 miRNAs indicated the role of miR-1205 in the initiation of gastric cancer development.

引用

页码：947 / 958

页数：12

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