GRADE approach to drawing conclusions from a network meta-analysis using a partially contextualised framework

被引：102

作者：

Brignardello-Petersen, Romina ^{[1
]}

Izcovich, Ariel ^{[2
]}

Rochwerg, Bram ^{[1
]}

Florez, Ivan D. ^{[1
,3
]}

Hazlewood, Glen ^{[4
]}

Alhazanni, Waleed ^{[1
]}

Yepes-Nunez, Juan ^{[5
]}

Santesso, Nancy ^{[1
]}

Guyatt, Gordon H. ^{[1
]}

Schunemann, Holger J. ^{[1
,6
,7
]}

机构：

[1] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1280 Main St West, Hamilton, ON L8S 4L8, Canada

[2] German Hosp, Internal Med Serv, Buenos Aires, DF, Argentina

[3] Univ Antioquia, Sch Med, Dept Pediat, Medellin, Colombia

[4] Univ Calgary, Cumming Sch Med, Dept Med, Calgary, AB, Canada

[5] Univ Andes, Sch Med, Bogota, Colombia

[6] McMaster Univ, GRADE Ctr, Hamilton, ON, Canada

[7] McMaster Univ, Dept Med, Hamilton, ON, Canada

来源：

BMJ-BRITISH MEDICAL JOURNAL | 2020年 / 371卷

关键词：

DECISION ETD FRAMEWORKS;

D O I：

10.1136/bmj.m3907

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article describes GRADE (grading of recommendations assessment, development and evaluation) guidance on how to make conclusions from a network meta-analysis of interventions that includes individual randomised controlled trials for one outcome at a time. The guidance is based on a partially contextualised approach in which review authors must establish ranges of magnitudes of effect that represent a trivial to no effect, small but important effect, moderate effect, and large effect. The principles guiding this framework are that interventions should be grouped in categories, based on the magnitude of the effect; and that the judgments that place interventions in such categories should consider the estimates of effect, the certainty of the evidence, and the rankings. We describe and illustrate the four steps of this framework using an example.

引用

页数：7

共 22 条

[21] GRADE guidelines: 20. Assessing the certainty of evidence in the importance of outcomes or values and preferences-inconsistency, imprecision, and other domains [J].

Zhang, Yuan ;

Alonso Coello, Pablo ;

Guyatt, Gordon H. ;

Yepes-Nunez, Juan Jose ;

Akl, Elie A. ;

Hazlewood, Glen ;

Pardo-Hernandez, Hector ;

Etxeandia-Ikobaltzeta, Itziar ;

Qaseem, Amir ;

Williams, John W., Jr. ;

Tugwell, Peter ;

Flottorp, Signe ;

Chang, Yaping ;

Zhang, Yuqing ;

Mustafa, Reem A. ;

Rojas, Maria Ximena ;

Xie, Feng ;

Schunemann, Holger J. .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 2019, 111 :83-93

[22] GRADE Guidelines: 19. Assessing the certainty of evidence in the importance of outcomes or values and preferences-Risk of bias and indirectness [J].