The association between low lean mass and osteoporosis increases the risk of weakness, poor physical performance and frailty in Brazilian older adults: data from SARCOS study

被引:7
作者
Frisoli Jr, Alberto [1 ,2 ]
Paes, Angela Tavares [3 ]
Borges, Jairo [1 ,2 ]
Ingham, Sheila McNeill [2 ]
Cartocci, Monica Maria [1 ]
Lima, Eliene [1 ]
de Camargo Carvalho, Antonio Carlos [1 ]
机构
[1] Univ Fed Sao Paulo, Div Cardiol, Geriatr Cardiol Clin, Escola Paulista Med, Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, Elderly Vulnerabil Dis Res Grp, Div Cardiol, Escola Paulista Med, Sao Paulo, SP, Brazil
[3] Univ Fed Sao Paulo, Dept Stat, Sao Paulo, Brazil
关键词
MUSCLE STRENGTH; GRIP STRENGTH; HIP FRACTURE; WOMEN; AGE; INFLAMMATION; SARCOPENIA; OBESITY; MEN; OSTEOSARCOPENIA;
D O I
10.1038/s41430-020-00753-w
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Purpose To characterize the phenotypes of older adults with low lean mass and osteoporosis, concomitantly or isolated, in regards to poor physical performance and frailty status. Design Cross-sectional analysis of the SARCopenia and OSteoporosis in Older Adults with Cardiovascular Diseases Study (SARCOS). Setting Outpatient geriatric cardiology clinic. Participants and method 385 older adults underwent DXA analysis. Low lean mass was diagnosed according to FNIH and low BMD by aT-score <= -2.5 SD. Subjects were grouped into: I-Low lean mass and Osteoporosis (LLMO); II-Low lean mass (LLM); III-Osteoporosis (OP), and IV-Controls. Poor physical performance was diagnosed by weakness or slow walking speed or impaired mobility. Frailty was diagnosed by CHS criteria. Results The mean age was 78.22 +/- 7.16 years. The prevalence of LLMO, LLM, and OP were 14.8%, 39.5%, and 19.2%, respectively. LLMO subjects were older, predominantly women, with a high percentage of body fat (HTBF). LLM was represented by obese men, while individuals with OP were preferably women, older and leaner. In a regression analyses, LLMO presented an OR: 6.42 (2.63-15.65;p < 0.001) for weakness, OR: 2.55 (1.09-5.95;p = 0.030) for impaired mobility, and OR: 14.75 (2.72-79.94;p = 0.002) for frailty. After adjusting for HTBF, the OR for frailty, decreased to 7.25 (1.11-47.21;p = 0.038). LLM and OP were associated only with weakness with an OR: 3.06 (1.36-6.84;p = 0.006) and OR: 3.14 (1.29-7.62;p = 0.011), respectively. Conclusion In Brazilian older community-dwelling outpatient adults, the phenotype characterized by low lean mass and osteoporosis presents a higher association with impaired mobility, weakness and frailty status compared to the others phenotyeps and controls. A high percentage of body fat presents a synergistic effect with low lean mass and osteoporosis phenotype in regards to frailty.
引用
收藏
页码:446 / 455
页数:10
相关论文
共 51 条
  • [31] Cytokine involvement in cancer anorexia/cachexia:: Role of megestrol acetate and medroxyprogesterone acetate on cytokine downregulation and improvement of clinical symptoms
    Mantovani, G
    Macciò, A
    Lai, P
    Massa, E
    Ghiani, M
    Santona, MC
    [J]. CRITICAL REVIEWS IN ONCOGENESIS, 1998, 9 (02): : 99 - 106
  • [32] Skeletal muscle fat infiltration: Impact of age, inactivity, and exercise
    Marcus, R. L.
    Addison, O.
    Kidde, J. P.
    Dibble, L. E.
    Lastayo, P. C.
    [J]. JOURNAL OF NUTRITION HEALTH & AGING, 2010, 14 (05) : 362 - 366
  • [33] Mo Chenglin, 2012, Recent Pat Biotechnol, V6, P223
  • [34] Relationships between serum adipocyte hormones (adiponectin, leptin, resistin), bone mineral density and bone metabolic markers in osteoporosis patients
    Mohiti-Ardekani, J.
    Soleymani-Salehabadi, H.
    Owlia, M. B.
    Mohiti, A.
    [J]. JOURNAL OF BONE AND MINERAL METABOLISM, 2014, 32 (04) : 400 - 404
  • [35] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    Nishimura, Satoshi
    Manabe, Ichiro
    Nagasaki, Mika
    Eto, Koji
    Yamashita, Hiroshi
    Ohsugi, Mitsuru
    Otsu, Makoto
    Hara, Kazuo
    Ueki, Kohjiro
    Sugiura, Seiryo
    Yoshimura, Kotaro
    Kadowaki, Takashi
    Nagai, Ryozo
    [J]. NATURE MEDICINE, 2009, 15 (08) : 914 - U116
  • [36] MUSCLE WEAKNESS IN WOMEN OCCURS AT AN EARLIER AGE THAN IN MEN, BUT STRENGTH IS PRESERVED BY HORMONE REPLACEMENT THERAPY
    PHILLIPS, SK
    ROOK, KM
    SIDDLE, NC
    BRUCE, SA
    WOLEDGE, RC
    [J]. CLINICAL SCIENCE, 1993, 84 (01) : 95 - 98
  • [37] Immunology of Osteoporosis: A Mini-Review
    Pietschmann, Peter
    Mechtcheriakova, Diana
    Meshcheryakova, Anastasia
    Foeger-Samwald, Ursula
    Ellinger, Isabella
    [J]. GERONTOLOGY, 2016, 62 (02) : 128 - 137
  • [38] Muscle Strength and Body Composition Are Clinical Indicators of Osteoporosis
    Rikkonen, Toni
    Sirola, Joonas
    Salovaara, Kari
    Tuppurainen, Marjo
    Jurvelin, Jukka S.
    Honkanen, Risto
    Kroger, Heikki
    [J]. CALCIFIED TISSUE INTERNATIONAL, 2012, 91 (02) : 131 - 138
  • [39] Burden of non-hip, non-vertebral fractures on quality of life in postmenopausal women The Global Longitudinal study of Osteoporosis in Women (GLOW)
    Roux, C.
    Wyman, A.
    Hooven, F. H.
    Gehlbach, S. H.
    Adachi, J. D.
    Chapurlat, R. D.
    Compston, J. E.
    Cooper, C.
    Diez-Perez, A.
    Greenspan, S. L.
    LaCroix, A. Z.
    Netelenbos, J. C.
    Pfeilschifter, J.
    Rossini, M.
    Saag, K. G.
    Sambrook, P. N.
    Silverman, S.
    Siris, E. S.
    Watts, N. B.
    Boonen, S.
    [J]. OSTEOPOROSIS INTERNATIONAL, 2012, 23 (12) : 2863 - 2871
  • [40] Sarcopenic obesity and inflammation in the InCHIANTI study
    Schrager, Matthew A.
    Metter, E. Jeffrey
    Simonsick, Eleanor
    Ble, Alessandro
    Bandinelli, Stefania
    Lauretani, Fulvio
    Ferrucci, Luigi
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2007, 102 (03) : 919 - 925