Congenital Kaposiform Hemangioendothelioma with Kasabach-Merritt Phenomenon Successfully Treated with Low-Dose Radiation Therapy

被引:21
作者
Malhotra, Yogangi [1 ,5 ]
Yang, Catherine S. [2 ,6 ]
McNamara, Joseph [3 ]
Antaya, Richard J. [3 ,4 ]
机构
[1] Yale Univ, Div Neonatol, New Haven, CT USA
[2] Yale Univ, Sch Med, New Haven, CT USA
[3] Yale Univ, Dept Pediat, New Haven, CT 06520 USA
[4] Yale Univ, Dept Dermatol, New Haven, CT 06520 USA
[5] New York Med Coll, Div Neonatol, Maria Fareri Childrens Hosp, Westchester, NY USA
[6] Massachusetts Gen Hosp, Dept Pediat, Boston, MA 02114 USA
关键词
HEMANGIOMA;
D O I
10.1111/pde.12090
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Kaposiform hemangioendothelioma (KHE) associated with Kasabach-Merritt phenomenon is a life-threatening vasculopathy. The current mainstay treatment for KHEs is corticosteroids and chemotherapy, but these medications do not work for all patients and carry significant side effects. We report a neonate with a large congenital KHE who responded extremely well to low-dose radiation therapy.
引用
收藏
页码:595 / 598
页数:4
相关论文
共 7 条
  • [1] Long-Term Effects of Radiation Exposure among Adult Survivors of Childhood Cancer: Results from the Childhood Cancer Survivor Study
    Armstrong, Gregory T.
    Stovall, Marilyn
    Robison, Leslie L.
    [J]. RADIATION RESEARCH, 2010, 174 (06) : 840 - 850
  • [2] Kaposiform hemangioendothelioma
    Fernandez, Y.
    Bernabeu-Wittel, M.
    Garcia-Morillo, J. S.
    [J]. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2009, 20 (02) : 106 - 113
  • [3] Use of radiotherapy to treat life-threatening Kasabach-Merritt syndrome
    Leong, E.
    Bydder, S.
    [J]. JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY, 2009, 53 (01) : 87 - 91
  • [4] Outcome of radiation therapy for patients with Kasabach-Merritt syndrome
    Mitsuhashi, N
    Furuta, M
    Sakurai, H
    Takahashi, T
    Kato, SG
    Nozaki, M
    Saito, Y
    Hayakawa, K
    Niibe, H
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1997, 39 (02): : 467 - 473
  • [5] Radiation therapy for life- or function-threatening infant hemangioma
    Ogino, I
    Torikai, K
    Kobayasi, S
    Aida, N
    Hata, M
    Kigasawa, H
    [J]. RADIOLOGY, 2001, 218 (03) : 834 - 839
  • [6] Kasabach-Merritt Phenomenon Case Series and Retrospective Review of the Mayo Clinic Experience
    Rodriguez, Vilmarie
    Lee, Adrianna
    Wittman, Patricia M.
    Anderson, Peter A.
    [J]. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2009, 31 (07) : 522 - 526
  • [7] Kaposiform hemangioendothelioma - An aggressive, locally invasive vascular tumor that can mimic hemangioma of infancy
    VinChristian, K
    McCalmont, TH
    Frieden, IJ
    [J]. ARCHIVES OF DERMATOLOGY, 1997, 133 (12) : 1573 - 1578