Synthesis of Certain New Thiazole and 1,3,4-Thiadiazole Derivatives via the Utility of 3-Acetylindole

被引：18

作者：

Abdelhamid, Abdou O. ^{[1
]}

Gomha, Sobhi M. ^{[1
]}

Kandeel, Saher M. ^{[2
]}

机构：

[1] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt

[2] Dept Natl Res Ctr, Chem Nat Cpds, Cairo, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 02期

关键词：

ANTIVIRAL ACTIVITY; HETEROCYCLES; ANALOGS;

D O I：

10.1002/jhet.2740

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-(2-(1-(1H-Indol-3-yl)ethylidene)-hydrazinyl)-4-substituted 5-(aryldiazenyl)thiazoles and 5-((1-(1H-indol-3-yl)ethylidene)hydrazono)-2-substituted-4-phenyl-4,5-dihydro-1,3,4-thiadiazoles were synthesized via reaction of hydrazonoyl halides and 2-(1-(1H-indol-3-yl)ethylidene)hydrazine-1-carbothioamide and alkyl 2-(1-(1H-indol-3-yl)ethylidene)hydrazine-1-carbodithioate in ethanolic triethylamine. Structures of the newly synthesis were elucidated on the basis of elemental analysis, spectral data, and alternative synthetic route whenever possible.

引用

页码：1529 / 1536

页数：8

共 28 条

[1] Synthesis and Antiviral Activity of New Indole-Based Heterocycles [J].

Abdel-Gawad, Hassan ;

Mohamed, Hanan Ahmed ;

Dawood, Kamal Mohamed ;

Badria, Farid Abdel-Rahem .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2010, 58 (11) :1529-1531

[2]

Abdelhamid A.O., 1999, J CHEM RES, V184, P920

[3] Synthesis of New Pyrazolo[ 1,5-a]pyrimidine, Triazolo[ 4,3-a] pyrimidine Derivatives, and Thieno[ 2,3-b] pyridine Derivatives from Sodium 3-(5-Methyl-1-phenyl-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-olate [J].

Abdelhamid, Abdou O. ;

Gomha, Sobhi M. .

JOURNAL OF CHEMISTRY, 2013, 2013

[4] REACTIONS WITH HYDRAZIDOYL HALIDES-II .1. SYNTHESIS AND REACTIONS OF 2-BROMOTHIENYLGLYOXAL-2-PHENYLHYDRAZONE [J].

ABDELHAMID, AO ;

ELSHIATY, FHH .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1988, 39 (1-2) :45-49

[5]

Adel A. E., 1993, PHARM SCI, V7, P99

[6]

AKAGI T, 1995, J PESTIC SCI, V20, P279

[7]

ALMERICO AM, 2000, ARKIVOC, P486

[8] Synthesis and antiviral evaluation of trisubstituted indole N-nucleosides as analogues of 2,5,6-trichloro-1-(β-D-ribofuranosyl)benzimidazole (TCRB) [J].

Chen, JJ ;

Wei, Y ;

Drach, JC ;

Townsend, LB .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (12) :2449-2456

[9]

DANDIA A, 1993, INDIAN J CHEM B, V32, P1288

[10]

Emam H. A., 1998, J CHEM RES S, V12

← 1 2 3 →