BNCT for advanced or recurrent head and neck cancer

被引：72

作者：

Aihara, Teruhito ^{[1
,2
]}

Morita, Norimasa ^{[2
]}

Kamitani, Nobuhiko ^{[3
]}

Kumada, Hiroaki ^{[1
]}

Ono, Koji ^{[4
]}

Hiratsuka, Junichi ^{[3
]}

Harada, Tamotsu ^{[2
]}

机构：

[1] Univ Tsukuba, Proton Med Res Ctr, Tsukuba, Ibaraki 3058575, Japan

[2] Dept Otolaryngol Head & Neck Surg, Tokyo, Japan

[3] Kawasaki Med Sch, Kurashiki, Okayama, Japan

[4] Kyoto Univ, Inst Res Reactor, Radiat Oncol Res Lab, Osaka 59004, Japan

来源：

APPLIED RADIATION AND ISOTOPES | 2014年 / 88卷

关键词：

Head and neck cancer; Recurrent SCC; Locally advanced non-SCC; BNCT; NEUTRON-CAPTURE THERAPY; SALIVARY-GLANDS; CARCINOMA;

D O I：

10.1016/j.apradiso.2014.04.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The therapeutic effect of surgery and/or combination of conventional chemoradiotherapy is limited in the patients with recurrent squamous cell carcinoma (SCC) and locally advanced non-squamous cell carcinoma without malignant melanoma (non-SCC) of the head and neck. Currently, clinical trials of BNCT for head and neck cancers are being conducted in some institutes to verify its the effectiveness. BNCT was performed in 10 patients with recurrent SCC, 7 patients with recurrent non-SCC and 3 patients with newly diagnosed non-SCC in our university between October 2003 and September 2007. Eleven patients showed complete remission and 7 patients showed partial remission of irradiated site. The effective rate [(CR+PR)/total cases] was 90%. No severe acute or chronic normal-tissue reactions were observed in any patients. BNCT is effective and safe in the patients with recurrent SCC and locally advanced non-SCC (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：12 / 15

页数：4

共 10 条

[1]

AIHARA T, 2006, P 12 INT C NEUTR CAP, P5

[2] Local-regional recurrence after surgery without postoperative irradiation for carcinomas of the major salivary glands: Implications for adjuvant therapy [J].

Chen, Allen M. ;

Granchi, Phillip J. ;

Garcia, Joaquin ;

Bucci, M. Kara ;

Fu, Karen K. ;

Eisele, David W. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 67 (04) :982-987

[3]

FU KK, 1977, CANCER, V40, P2882, DOI 10.1002/1097-0142(197712)40:6<2882::AID-CNCR2820400618>3.0.CO

[4]

2-I

[5]

Imahori Y, 1998, CLIN CANCER RES, V4, P1833

[6] Boron neutron capture therapy in the treatment of locally recurred head and neck cancer [J].

Kankaanranta, Leena ;

Seppala, Tiina ;

Koivunoro, Hanna ;

Saarilahti, Kauko ;

Atula, Timo ;

Collan, Juhani ;

Salli, Eero ;

Kortesniemi, Mika ;

Uusi-Simola, Jouni ;

Makitle, Antti ;

Seppanen, Marko ;

Minn, Heikki ;

Kotiluoto, Petri ;

Auterinen, Iiro ;

Savolainen, Sauli ;

Kouri, Mauri ;

Joensuu, Heikki .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 69 (02) :475-482

[7]

Kumada H., 2001, Proceedings of the 2000 Workshop on the Utilization of Research Reactors (JAERI-Conf 2001-017), P357

[8]

Nigg D. W., 1999, Transactions of the American Nuclear Society, V80, P66

[9]

Ono K., 2006, ADV NEUTRON CAPTURE, P27

[10] A phase II evaluation of a 3-hour infusion of paclitaxel, cisplatin, and 5-fluorouracil in patients with advanced or recurrent squamous cell carcinoma of the head and neck - Southwest Oncology Group study 0007 [J].

Worden, Francis P. ;

Moon, James ;

Samlowski, Wolfram ;

Clark, Joseph I. ;

Dakhil, Shaker R. ;

Williamson, Stephen ;

Urba, Susan G. ;

Ensley, John ;

Hussain, Maha H. .

CANCER, 2006, 107 (02) :319-327

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