Protamine sulfate-nanodiamond hybrid nanoparticles as a vector for MiR-203 restoration in esophageal carcinoma cells

被引：49

作者：

Cao, Minjun ^{[1
]}

Deng, Xiongwei ^{[1
]}

Su, Shishuai ^{[2
]}

Zhang, Fang ^{[1
]}

Xiao, Xiangqian ^{[1
]}

Hu, Qin ^{[1
]}

Fu, Yongwei ^{[1
]}

Yang, Burton B. ^{[3
]}

Wu, Yan ^{[2
]}

Sheng, Wang ^{[1
]}

Zeng, Yi ^{[1
]}

机构：

[1] Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China

[2] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M4N 3M5, Canada

来源：

NANOSCALE | 2013年 / 5卷 / 24期

基金：

国家高技术研究发展计划(863计划);

关键词：

RAN GTPASE; MICRORNA DELIVERY; SIRNA DELIVERY; EXPRESSION; PROLIFERATION; METASTASIS; GENOMICS; P63;

D O I：

10.1039/c3nr04056a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report an innovative approach for miRNA-203 delivery in esophageal cancer cells using protamine sulphate (PS)-nanodiamond (ND) nanoparticles. The efficient delivery of miR-203 significantly suppressed the proliferation and migration of cancer cells through targeting Ran and DNp63, exhibiting a great potential for PS@ND nanoparticles in miRNA-based cancer therapy.

引用

页码：12120 / 12125

页数：6

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