A Patient with Nephrotic-Range Proteinuria and Focal Global Glomerulosclerosis

被引：28

作者：

Fervenza, Fernando C. ^{[1
]}

机构：

[1] Mayo Clin, Coll Med, Div Nephrol & Hypertens, Rochester, MN 55901 USA

来源：

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2013年 / 8卷 / 11期

关键词：

MOLECULAR-WEIGHT PROTEINURIA; SEGMENTAL GLOMERULOSCLEROSIS; CHLORIDE CHANNEL; DENTS-DISEASE; CLINICAL CHARACTERISTICS; GENETIC-HETEROGENEITY; IMPAIRS ENDOCYTOSIS; MOUSE MODEL; CLC-5; MUTATIONS;

D O I：

10.2215/CJN.03400313

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A young male is evaluated for nephrotic-range proteinuria, hypercalciuria, and an elevated serum creatinine. A renal biopsy is performed and shows focal global glomerulosclerosis. The absence of nephrotic syndrome suggest that glomerulosclerosis was a secondary process. Further analysis of the proteinuria showed it to be due mainly to low-molecular weight proteins. The case illustrates the crucial role of electron microscopy as well as evaluation of the identity of the proteinuria that accompanies a biopsy finding of focal and global or focal and segmental glomerulosclerosis.

引用

页码：1979 / 1987

页数：9

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