Vascularisation of the central nervous system

被引：101

作者：

Tata, Mathew ^{[1
]}

Ruhrberg, Christiana ^{[1
]}

Fantin, Alessandro ^{[1
]}

机构：

[1] UCL, UCL Inst Ophthalmol, London EC1V 9EL, England

来源：

MECHANISMS OF DEVELOPMENT | 2015年 / 138卷

基金：

英国惠康基金;

关键词：

VEGF; Semaphorin; Neuropilin; GPCR; WNT; BRAIN-BARRIER INTEGRITY; OXYGEN-INDUCED RETINOPATHY; PROTEIN-COUPLED RECEPTOR; GROWTH-FACTOR VEGF; NEUROVASCULAR DEVELOPMENT; RETINAL ANGIOGENESIS; CEREBRAL-HEMORRHAGE; ENDOTHELIAL-CELLS; BLOOD-VESSELS; DEVELOPMENTAL ANGIOGENESIS;

D O I：

10.1016/j.mod.2015.07.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The developing central nervous system (CNS) is vascularised through the angiogenic invasion of blood vessels from a perineural vascular plexus, followed by continued sprouting and remodelling until a hierarchical vascular network is formed. Remarkably, vascularisation occurs without perturbing the intricate architecture of the neurogenic niches or the emerging neural networks. We discuss the mouse hind brain, forebrain and retina as widely used models to study developmental angiogenesis in the mammalian CNS and provide an overview of key cellular and molecular mechanisms regulating the vascularisation of these organs. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.

引用

页码：26 / 36

页数：11

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