Medical applications of magnetic nanoparticles

被引:101
作者
Alexiou, C. [1 ]
Jurgons, R. [1 ]
Seliger, C. [1 ]
Iro, H. [1 ]
机构
[1] Univ Erlangen Nurnberg, Dept Otorhinolaryngol Head & Neck Surg, D-8520 Erlangen, Germany
关键词
D O I
10.1166/jnn.2006.464
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In recent years biomedical research indicated, that magnetic nanoparticles can be a promising tool for several applications in vitro and in vivo. In medicine many approaches were investigated for diagnosis and therapy and offered a great variety of applications. Magnetic cell separation, magnetic resonance imaging (MRI), magnetic targeted delivery of therapeutics or magnetically induced hyperthermia are approaches of particular clinical relevance. For medical use, especially for in vivo application it is of great importance that these particles do not have any toxic effects or incompatibility with biological organism. Investigations on applicable particles induced a variability of micro- and nanostructures with different materials, sizes, and specific surface chemistry.
引用
收藏
页码:2762 / 2768
页数:7
相关论文
共 100 条
  • [1] Distribution of mitoxantrone after magnetic drug targeting: Fluorescence microscopic investigations on VX2 squamous cell carcinoma cells
    Alexiou, C
    Jurgons, R
    Seliger, C
    Kolb, S
    Heubeck, B
    Iro, H
    [J]. ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS, 2006, 220 (02): : 235 - 240
  • [2] In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles
    Alexiou, C
    Jurgons, R
    Schmid, R
    Hilpert, A
    Bergemann, C
    Parak, F
    Iro, H
    [J]. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2005, 293 (01) : 389 - 393
  • [3] Magnetic Drug Targeting - A new approach in locoregional tumortherapy with chemotherapeutic agents. Experimental animal studies
    Alexiou C.
    Jurgons R.
    Schmid R.
    Erhardt W.
    Parak F.
    Bergemann C.
    Iro H.
    [J]. HNO, 2005, 53 (7) : 618 - 622
  • [4] Magnetic drug targeting - Biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment
    Alexiou, C
    Jurgons, R
    Schmid, RJ
    Bergemann, C
    Henke, J
    Erhardt, W
    Huenges, E
    Parak, F
    [J]. JOURNAL OF DRUG TARGETING, 2003, 11 (03) : 139 - 149
  • [5] Alexiou C, 2000, CANCER RES, V60, P6641
  • [6] Magnetic mitoxantrone nanoparticle detection by histology, X-ray and MRI after magnetic tumor targeting
    Alexiou, C
    Arnold, W
    Hulin, P
    Klein, RJ
    Renz, H
    Parak, FG
    Bergemann, C
    Lübbe, AS
    [J]. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2001, 225 (1-2) : 187 - 193
  • [7] ALEXIOU C, 2006, EUR BIOPHYS J 0131
  • [8] ALEXIOU C, IN PRESS IEEE T APPL
  • [9] ALEXIOU C, IN PRESS ANTICANCER
  • [10] Alexiou C., 2001, MAGNETOHYDRODYNAMICS, V37, P318