Tumor-infiltrating lymphocytes in breast cancer A new predictor for responses to therapy

被引：22

作者：

Issa-Nummer, Yasmin ^{[1
]}

Loibl, Sibylle ^{[1
]}

von Minckwitz, Gunter ^{[1
]}

Denkert, Carsten ^{[2
]}

机构：

[1] German Breast Grp, Neu Isenburg, Germany

[2] Charite, Inst Pathol, D-13353 Berlin, Germany

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 02期

关键词：

biological marker; breast cancer; neoadjuvant chemotherapy; response predictor; NEOADJUVANT CHEMOTHERAPY; DOCETAXEL;

D O I：

10.4161/onci.27926

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have prospectively validated in an independent clinical cohort the finding that elevated amounts of tumor-infiltrating lymphocytes in breast carcinoma tissues predict the response of patients to neoadjuvant chemotherapy. These results suggest that a robust tumor infiltration by T and B cells is a promising biomarker to define patients who might benefit from neoadjuvant chemotherapy.

引用

页数：3

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