Improved GC for Isosorbide-5-mononitrate Determination in Dog Plasma and Its Application in Pharmacokinetics

被引：1
作者：
Duan, Xueyan [1 ,2 ]
Liu, Qingfei [2 ]
Su, Qiang [1 ]
Bi, Kaishun [1 ]
Wang, Yiming [2 ]
Luo, Guoan [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Dept Pharmaceut, Shenyang 110016, Peoples R China
[2] Tsinghua Univ, Inst Biomed, Beijing 100084, Peoples R China
来源：
CHROMATOGRAPHIA | 2009年 / 69卷 / 7-8期
关键词：
Gas chromatography; O-Dinitrobenzene; Isosorbide-5-mononitrate in dog plasma; CHROMATOGRAPHY MASS-SPECTROMETRY; GAS-CHROMATOGRAPHY; ISOSORBIDE; 5-MONONITRATE; DINITRATE;
D O I：
10.1365/s10337-009-0960-z
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The existing methods for the extraction and determination of isosorbide-5-mononitrate (5-ISMN) in biological samples are too complicated, poorly reproducible, and time-consuming. Therefore a procedure is described for the extraction of 5-ISMN from plasma with ethyl acetate and saturated potassium carbonate solution. The procedure of extraction is simple, and has a high recovery. At the same time, an improved, simple, rapid, and specific analytical method for the determination of 5-ISMN in dog plasma by capillary gas chromatography with electron-capture detection was developed. O-Dinitrobenzene was used as an internal standard. This method was successfully applied to a pharmacokinetic study on 5-ISMN.
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收藏
页码：799 / 802
页数：4
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