Synthesis and Characterization of 7-(3-(substituted-phenoxy) propoxy) Quinazoline Derivatives

被引：1
|
作者：
Yan He-ping [1 ,2 ]
Ouyang Gui-ping [3 ]
机构：
[1] Honghe Univ, Coll Sci, Mengzi 661100, Yunnan, Peoples R China
[2] Honghe Univ, Key Lab Nat Pharmaceut & Chem Biol Yunan Prov, Mengzi 661100, Yunnan, Peoples R China
[3] Gulzhou Univ, Minist Educ, Res & Dev Ctr Fine chem, Key Lab Green Presticide & Agr Bioengn, Gulzhou, Peoples R China
来源：
ADVANCES IN CHEMICAL ENGINEERING III, PTS 1-4 | 2013年 / 781-784卷
关键词：
4-(3 '-chlorophenylamino)-6-methoxy quinazoline; quinazoline derivatives; synthesis; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; ANTITUMOR-ACTIVITY; CANCER; DESIGN; POTENT; EGFR; DOMAIN;
D O I：
10.4028/www.scientific.net/AMR.781-784.1003
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Four compounds of 7-(3- (substituted-phenoxy) propoxy) quinazoline compounds, including 7-(3-(2,4-dichlorophenoxy)propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 7-(3-(2-chlo- rophenoxy)propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 7-(3-(4-chlorophenoxy)prop- oxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 7-(3-(naphthalen-3-yloxy)propoxy)-N-(3-chl- orophenyl)-6-methoxyquinazolin-4-amine, were synthesized from N'-(5-(3-chloropropoxy)-2-cyano- 4-methoxyphen-yl)-N, N-dimethylformamidine by cyclization, etheration, in the yield of 45.9%, 50.6%, 56.34% and 80.6% respectively. Their structures were characterized by IR, H-1 NMR, C-13 NMR, MS and elemental analysis.
引用
收藏
页码：1003 / +
页数：2
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