Synthesis and Characterization of 7-(3-(substituted-phenoxy) propoxy) Quinazoline Derivatives

Four compounds of 7-(3- (substituted-phenoxy) propoxy) quinazoline compounds, including 7-(3-(2,4-dichlorophenoxy)propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 7-(3-(2-chlo- rophenoxy)propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 7-(3-(4-chlorophenoxy)prop- oxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 7-(3-(naphthalen-3-yloxy)propoxy)-N-(3-chl- orophenyl)-6-methoxyquinazolin-4-amine, were synthesized from N'-(5-(3-chloropropoxy)-2-cyano- 4-methoxyphen-yl)-N, N-dimethylformamidine by cyclization, etheration, in the yield of 45.9%, 50.6%, 56.34% and 80.6% respectively. Their structures were characterized by IR, H-1 NMR, C-13 NMR, MS and elemental analysis.