Immunohistochemical expression of syndecan-1 in oral dysplastic epithelium

被引：10

作者：

Lakkam, B. ^{[1
]}

Majage, B. ^{[2
]}

Astekar, M. ^{[3
]}

Gugwad, R. S. ^{[2
]}

Giri, G. ^{[4
]}

Ramasahayam, S. ^{[5
]}

机构：

[1] Al Ameen Dent Coll, Dept Oral Pathol, Bijapur, India

[2] S Nijalingappa Inst Dent Sci, Dept Prosthodont, Gulbarga, India

[3] Pacific Dent Coll, Dept Oral Pathol, Udaipur, India

[4] S Nijalingappa Inst Dent Sci, Dept Periodont, Gulbarga, India

[5] SVS Inst Dent Sci, Dept Oral Pathol, Mahboobnagar, India

来源：

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | 2014年 / 10卷 / 01期

关键词：

Cell adhesion molecule; human intercellular adhesion molecule; malignant transformation; oral epithelial dysplasia; squamous cell carcinoma; syndecan; CELL-SURFACE PROTEOGLYCAN; HEPARAN-SULFATE PROTEOGLYCAN; EXTRACELLULAR-MATRIX; ADHESION MOLECULES; TUMOR PATHOLOGY; ASSOCIATION; MESENCHYME; CARCINOMA; BEHAVIOR; TOOLS;

D O I：

10.4103/0973-1482.131407

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: In stratified squamous epithelia, syndecan-1 is proposed to function as a cellto cell adhesion molecule, and plays an important role in regulation of cell growth and differentiation during the developmental process. Oral cancer is a disease with complex etiology, so biological behavior in carcinomas preceded by dysplastic states is difficult to assess and predict its prognosis. Hence, syndecan-1, a recently recognized tumor marker has been proved to be an eminent diagnostic and prognostic tool in assessing biological behavior of various potentially premalignant andmalignant lesions. Materials and Methods: The study group consisted of 40 specimens of premalignant stateand 10 specimens of normal mucosa. Thesections were stained withhematoxylin and eosin, andimmunohistochemicallyusing syndecan-1 a primary antibody and was observed under light microscope. Results: Expression decreased with the decreasing grades of dysplasia. Conclusion: Syndecan-1 can be efficiently used in early detection and diagnosis of oral carcinoma.

引用

页码：103 / 106

页数：4