The systemic reaction during inflammation: The acute-phase proteins

被引：187

作者：

Ceciliani, F ^{[1
]}

Giordano, A ^{[1
]}

Spagnolo, V ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Patol Anim Igiene & Sanita Publ Vet, I-20133 Milan, Italy

来源：

PROTEIN AND PEPTIDE LETTERS | 2002年 / 9卷 / 03期

关键词：

acute-phase; serum amyloid; inflammation; systemic response;

D O I：

10.2174/0929866023408779

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The acute-phase response consists in a large number of behavioural, physiologic, biochemical, and nutritional changes involving many organ systems distant from the site, or sites, of inflammation. One of the most investigated, but still not well understood, characteristic of the acute phase is the up-regulation, or down-regulation, of many plasma proteins, known as the acute-phase proteins. The changes in the concentrations of these positive acute-phase proteins and negative acute-phase proteins are due to changes in their liver production. Their increase may vary from 25 percent to 1000 fold, as in the case of C-reactive protein and serum amyloid A. This review summarises the recent advances that have been acquired on the acute-phase proteins, in particular their function in pathologies such as infections or inflammatory lesions.

引用

页码：211 / 223

页数：13

共 56 条

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