Epithelial cell proliferation in nasal polyps could be up-regulated by platelet-derived growth factor

被引：40

作者：

Coste, A ^{[1
]}

Wang, QP ^{[1
]}

RoudotThoraval, F ^{[1
]}

Chapelin, C ^{[1
]}

Bedbeder, P ^{[1
]}

Poron, F ^{[1
]}

Peynegre, R ^{[1
]}

Escudier, E ^{[1
]}

机构：

[1] UNIV PARIS 12,FAC MED,UNITE EVALUAT CLIN & BIOSTAT,CRETEIL,FRANCE

来源：

LARYNGOSCOPE | 1996年 / 106卷 / 05期

关键词：

D O I：

10.1097/00005537-199605000-00011

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The modifications of epithelial differentiation and proliferation observed in nasal polyps (NP) could be related to local secretion of growth factors, among which platelet-derived growth factor (PDGF) could play a key role. We therefore prospectively studied, by immunohistochemistry, proliferating cell nuclear antigen (PCNA, and S-phase cell marker), PDGF, and CD-68 (activated macrophages marker) expression in NP and inferior turbinate mucosa (NM) in 11 patients. Our data show that PCNA and PDGF expression are increased in NP epithelium, while CD-68 expression is increased in NP epithelium and lamina propria when compared to NM. Increased local PDGF secretion by numerous activated macrophages could therefore be involved in epithelial cell proliferation up-regulation in NP. PDGF could also be involved in the pathogenesis of NP via its connective tissue remodeling actions.

引用

页码：578 / 583

页数：6

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