Dynamics of transposable elements generates structure and symmetries in genetic sequences

被引：1

作者：

Cristadoro, Giampaolo ^{[1
]}

Esposti, Mirko Degli ^{[2
]}

Altmann, Eduardo G. ^{[3
]}

机构：

[1] Univ Milano Bicocca, Dipartimento Matemat & Applicaz, Via Roberto Cozzi 55, I-20125 Milan, Italy

[2] Univ Bologna, Dept Comp Sci & Engn, Mura Anteo Zamboni 7, I-40126 Bologna, Italy

[3] Univ Sydney, Sch Math & Stat F07, Sydney, NSW 2006, Australia

来源：

PHYSICAL REVIEW RESEARCH | 2020年 / 2卷 / 03期

关键词：

LONG-RANGE CORRELATIONS; FRACTAL CORRELATIONS; DNA TRANSPOSONS; EVOLUTION; DEVIATIONS; STRANDS; GENOME;

D O I：

10.1103/PhysRevResearch.2.033477

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Genetic sequences are known to possess nontrivial composition together with symmetries in the frequencies of their components. Recently, it has been shown that symmetry and structure are hierarchically intertwined in DNA, suggesting a common origin for both features. However, the mechanism leading to this relationship is unknown. Here we investigate a biologically motivated dynamics for the evolution of genetic sequences. We show that a metastable (long-lived) regime emerges in which sequences have symmetry and structure interlaced in a way that matches that of extant genomes.

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页数：6

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