The pH of the reaction controls the stereoselectivity of organocatalyzed direct aldol reactions in water

被引：41

作者：

Chimni, Swapandeep Singh ^{[1
]}

Singh, Sarbjit ^{[1
]}

Kumar, Akshay ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Chem, Amritsar 143005, Punjab, India

来源：

TETRAHEDRON-ASYMMETRY | 2009年 / 20卷 / 15期

关键词：

SMALL ORGANIC-MOLECULE; AQUEOUS-MEDIA; BRONSTED ACIDS; CATALYSIS; ENAMINE; PROLINE;

D O I：

10.1016/j.tetasy.2009.07.014

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The direct aldol reaction of 4-nitrobenzaldehyde and cyclohexanone, catalyzed by a protonated prolinamide catalyst in water, proceeds with the formation of aldol product that has high diastereoselectivity and enantioselectivity in an optimal pH range of 4-5. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1722 / 1724

页数：3

共 24 条

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