Enteral feeding and early outcomes of patients undergoing allogeneic stem cell transplantation following myeloablative conditioning

被引:84
作者
Seguy, David
Berthon, Celine
Micol, Jean-Baptiste
Darre, Stephane
Dalle, Jean-Hugues
Neuville, Sylvain
Bauters, Francis
Jouet, Jean-Pierre
Yakoub-Agha, Ibrahim
机构
[1] CHU Lille, Serv Nutr, F-59037 Lille, France
[2] CHU Lille, Serv Malad Sang, F-59037 Lille, France
[3] CHU Lille, Secteur Nutr, F-59037 Lille, France
关键词
enteral nutrition; allogeneic stem cell transplantation; infection; early complications;
D O I
10.1097/01.tp.0000229419.73428.ff
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The purpose of this study was to evaluate the impact of enteral nutrition on early outcome of patients after myeloablative allogeneic stem cell transplantation (allo-SCT). From January 2001 to January 2003, 22 patients agreed to receive enteral nutrition via a nasogastric feeding tube; the remaining 23 patients received parenteral nutrition (n=22) or standard oral feeding (n=1). Early complications and factors influencing 100-day overall survival (OS) were investigated. Patients who received enteral nutrition developed less often acute-grade III/IV graft-versus-host disease (18%) than those who did not (35%) (P=0.011). In addition, this group showed lower mortality from infection during the first 100 days after transplantation. In multivariate analyses, only the absence of enteral nutrition was found to adversely influence 100-day OS with a hazard ratio of 8.3. Enteral nutrition is a safe and effective method for feeding allo-SCT patients. A randomized trial is warranted to confirm its advantage on early patient outcome.
引用
收藏
页码:835 / 839
页数:5
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