The JAK1/2 inhibitor ruxolitinib induces cell cycle arrest and apoptosis through inhibiting STAT3 phosphorylation in squamous cell carcinoma

被引:0
|
作者
Jackow, J. [1 ]
Perez-Lorenzo, R. [1 ]
Hansen, C. [1 ]
Owens, D. [1 ]
Christiano, A. [1 ]
机构
[1] Columbia Univ, Dermatol, New York, NY USA
关键词
D O I
10.1016/j.jid.2018.03.203
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
198
引用
收藏
页码:S34 / S34
页数:1
相关论文
共 50 条
  • [41] Down-regulation of STAT3 induces the apoptosis and G1 cell cycle arrest in esophageal carcinoma ECA109 cells
    Chao Zhou
    Jie Ma
    Mengyuan Su
    Dan Shao
    Jianan Zhao
    Tongjian Zhao
    Zhuoyao Song
    Yan Meng
    Ping Jiao
    Cancer Cell International, 18
  • [42] Down-regulation of STAT3 induces the apoptosis and G1 cell cycle arrest in esophageal carcinoma ECA109 cells
    Zhou, Chao
    Ma, Jie
    Su, Mengyuan
    Shao, Dan
    Zhao, Jianan
    Zhao, Tongjian
    Song, Zhuoyao
    Meng, Yan
    Jiao, Ping
    CANCER CELL INTERNATIONAL, 2018, 18
  • [43] Breviscapine Induces Breast Cancer Cell Cycle Arrest and Apoptosis by Modulating the Jak-Stat Pathway
    Zhang, Lan
    Lu, Yuqin
    Yin, Siyuan
    Luo, Yaobing
    CURRENT TOPICS IN NUTRACEUTICAL RESEARCH, 2020, 18 (01) : 83 - 88
  • [44] Allogeneic hematopoietic cell transplantation for myelofibrosis in patients pretreated with the JAK1 and JAK2 inhibitor ruxolitinib
    Jaekel, N.
    Behre, G.
    Behning, A.
    Wickenhauser, C.
    Lange, T.
    Niederwieser, D.
    Al-Ali, H. K.
    BONE MARROW TRANSPLANTATION, 2014, 49 (02) : 179 - 184
  • [45] Allogeneic hematopoietic cell transplantation for myelofibrosis in patients pretreated with the JAK1 and JAK2 inhibitor ruxolitinib
    N Jaekel
    G Behre
    A Behning
    C Wickenhauser
    T Lange
    D Niederwieser
    H K Al-Ali
    Bone Marrow Transplantation, 2014, 49 : 179 - 184
  • [46] Salidroside reduces renal cell carcinoma proliferation by inhibiting JAK2/STAT3 signaling
    Lv, Cai
    Huang, Yuan
    Liu, Zhen-Xiang
    Yu, Dan
    Bai, Zhi-Ming
    CANCER BIOMARKERS, 2016, 17 (01) : 41 - 47
  • [47] PRECLINICAL ACTIVITY OF THE JAK1/2 INHIBITOR RUXOLITINIB ON MALIGNANT PLASMA CELL GROWTH AND SURVIVAL
    Burger, R.
    Bugdahn, T.
    Staudinger, M.
    Peipp, M.
    Guenther, A.
    Gramatzki, M.
    HAEMATOLOGICA, 2012, 97 : 438 - 439
  • [48] A PKM2 inhibitor induces apoptosis and autophagy through JAK2 in human oral squamous cell carcinoma cells
    Weng, Jing-Ru
    Gopula, Balraj
    Chu, Po-Chen
    Hu, Jing-Lan
    Feng, Chia-Hsien
    CHEMICO-BIOLOGICAL INTERACTIONS, 2023, 380
  • [49] Ruxolitinib induces apoptosis of human colorectal cancer cells by downregulating the JAK1/2-STAT1-Mcl-1 axis
    Li, Xia
    Wang, Zhe
    Zhang, Shengjie
    Yao, Qinghua
    Chen, Wei
    Liu, Feiyan
    ONCOLOGY LETTERS, 2021, 21 (05)
  • [50] Alpinumisoflavone radiosensitizes esophageal squamous cell carcinoma through inducing apoptosis and cell cycle arrest
    Zhang, Bin
    Fan, Xinglong
    Wang, Zhen
    Zhu, Wenyong
    Li, Jingbo
    BIOMEDICINE & PHARMACOTHERAPY, 2017, 95 : 199 - 206