The use of amino acid PET and conventional MRI for monitoring of brain tumor therapy

被引：89

作者：

Galldiks, Norbert ^{[1
,2
,3
,4
]}

Law, Ian ^{[5
]}

Pope, Whitney B. ^{[6
]}

Arbizu, Javier ^{[7
]}

Langen, Karl-Josef ^{[2
,8
]}

机构：

[1] Univ Cologne, Dept Neurol, Cologne, Germany

[2] Forschungszentrum Julich, Inst Neurosci & Med, D-52425 Julich, Germany

[3] Univ Cologne, CIO, Cologne, Germany

[4] Univ Bonn, Cologne, Germany

[5] Univ Copenhagen, Rigshosp, Dept Clin Physiol Nucl Med & PET, Copenhagen, Denmark

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, Los Angeles, CA 90095 USA

[7] Univ Navarra, Clin Univ Navarra, Dept Nucl Med, Pamplona, Spain

[8] Univ Aachen, Dept Nucl Med, Aachen, Germany

来源：

NEUROIMAGE-CLINICAL | 2017年 / 13卷

关键词：

PET; FET; MET; FDOPA; Glioma; Temozolomide; Bevacizumab; Immunotherapy; Checkpoint inhibitors; Pseudoprogression; Pseudoresponse; POSITRON-EMISSION-TOMOGRAPHY; RECURRENT MALIGNANT GLIOMA; DYNAMIC F-18-FET PET; HIGH-GRADE GLIOMAS; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; TREATMENT RESPONSE; RADIATION NECROSIS; TEMOZOLOMIDE CHEMOTHERAPY; GLIOBLASTOMA-MULTIFORME; IMAGING PROLIFERATION;

D O I：

10.1016/j.nicl.2016.12.020

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Routine diagnostics and treatment monitoring of brain tumors is usually based on contrast-enhanced MRI. However, the capacity of conventional MRI to differentiate tumor tissue from posttherapeutic effects following neurosurgical resection, chemoradiation, alkylating chemotherapy, radiosurgery, and/or immunotherapy may be limited. Metabolic imaging using PET can provide relevant additional information on tumor metabolism, which allows for more accurate diagnostics especially in clinically equivocal situations. This review article focuses predominantly on the amino acid PET tracers C-11-methyl-L-methionine (MET), O-(2-[F-18] fluoroethyl)-L-tyrosine (FET) and 3,4-dihydroxy-6-[F-18]-fluoro-L-phenylalanine (FDOPA) and summarizes investigations regarding monitoring of brain tumor therapy. (C) 2016 The Authors. Published by Elsevier Inc.

引用

页码：386 / 394

页数：9

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