Target Nuclear Factor Erythroid 2-Related Factor 2 in Pulmonary Hypertension: Molecular Insight into Application

被引：8

作者：

Qin, Yuhan ^{[1
]}

Qiao, Yong ^{[1
]}

Wang, Dong ^{[1
]}

Li, Linqing ^{[1
]}

Li, Mingkang ^{[1
]}

Yan, Gaoliang ^{[1
]}

Tang, Chengchun ^{[1
]}

机构：

[1] Southeast Univ, Zhongda Hosp, Sch Med, Dept Cardiol, Nanjing, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2022年 / 2022卷

基金：

中国国家自然科学基金;

关键词：

NADPH OXIDASE 1; OXIDATIVE STRESS; ARTERIAL-HYPERTENSION; TRANSCRIPTION FACTOR; SALVIANOLIC ACID; MESENCHYMAL TRANSITION; BARDOXOLONE METHYL; REACTIVATES NRF2; ANTIOXIDANT; EXPRESSION;

D O I：

10.1155/2022/7845503

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor involved in maintaining redox balance and activates the expression of downstream antioxidant enzymes. Nrf2 has received wide attention considering its crucial role in oxidative and electrophilic stress. Large amounts of studies have demonstrated the protective role of Nrf2 activation in various pulmonary hypertension (pH) models. Additionally, various kinds of natural phytochemicals acting as Nrf2 activators prevent the development of pH and provide a novel and promising therapeutic insight for the treatment of pH. In the current review, we give a brief introduction of Nrf2 and focus on the role and mechanism of Nrf2 in the pathophysiology of pH and then review the relevant research of Nrf2 agonists in pH in both experimental research and clinical trials.

引用

页数：14

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