Elastic Averaging for Assembly of Three-Dimensional Constructs From Elastomeric Micromolded Layers

被引:4
作者
Marentis, Theodore C. [1 ,2 ,3 ,4 ]
Vacanti, Joseph P. [3 ,5 ]
Hsiao, James C. [2 ]
Borenstein, Jeffrey T. [2 ]
机构
[1] Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[2] Charles Stark Draper Lab Inc, Cambridge, MA 02139 USA
[3] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA
[4] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA
[5] Massachusetts Gen Hosp, Dept Pediat Surg, Boston, MA 02114 USA
关键词
Alignment; biomedical engineering; elastic averaging; lab-on-a-chip; microassembly; microfluidics; micromachining; poly-(dimethylsiloxane) (PDMS); precision engineering; silicone rubbers; surface fitting; tissue engineering; MICROFLUIDIC SYSTEMS; TISSUE; FABRICATION; SCAFFOLDS; CELLS; LIVER; PDMS;
D O I
10.1109/JMEMS.2009.2018372
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Precision engineering has been used in the macro-world and in the microscale only with rigid materials. Soft flexible materials commonly used for microfluidics and other bio-MEMS applications have not been aligned with elastic averaging. We report the use of complementary raised and recessed circular features to align polymer layers and demonstrate alignment accuracy and repeatability. The alignment is accomplished in a Petri dish with a thin layer of liquid between the two surfaces of micromolded elastomeric polymer sheets. The layers are aligned with simple hand-eye manipulation. We test circular geometries of varying diameters, obtaining accuracy and repeatability values in the range of 1-3 mu m across thin polymer sheets molded from silicon masters. This is a significant improvement over existing manual, moving stage, and self-alignment techniques and a novel proof of concept that paves the way for complex 3-D polymer constructs. [2008-0093]
引用
收藏
页码:531 / 538
页数:8
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