The antiproliferative activity of saponin-enriched fraction from Bupleurum kaoi is through Fas-dependent apoptotic pathway in human non-small cell lung cancer A549 cells

被引：25
作者：
Hsu, YL
Kuo, PL
Weng, TC
Yen, MH
Chiang, LC
Lin, CC
机构：
[1] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
[2] Chia Nan Univ Pharm & Sci, Dept Pharm, Tainan 717, Taiwan
[3] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung 80708, Taiwan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2004年 / 27卷 / 07期
关键词：
saponin-enriched fraction; Bupleurum kaoi; fas; fas ligand; apoptosis;
D O I：
10.1248/bpb.27.1112
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Bupleuri Radix (Chai-hu in Chinese and Saiko in Japanese) is one of the most important traditional Chinese crude drugs for treating hepatitis malaria and intermittent fever. B. kaoi is one of the Bupleurum spp. families locally found in Taiwan. The effects of saponin-enriched fraction (SEF) from Bapleurum Kaoi in human non-small cell lung cancer A549 cells were investigated in this study. An enhancement in Fas and its two forms of ligands, membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), was responsible for the apoptotic effect induced by SEE Taken together, our study suggests that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of SEF in A549 cells.
引用
收藏
页码：1112 / 1115
页数：4
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