Stimulating effect of a new triterpene derived from Anoectochilus elwesii on glucose uptake in insulin-resistant human HepG2 cells

被引：8

作者：

Cai, Jinyan ^{[1
]}

Zhao, Lin ^{[2
]}

Zhu, En ^{[1
]}

Guo, Jiao ^{[3
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China

[2] Guangdong Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Guangzhou 510006, Guangdong, Peoples R China

[3] Guangdong Pharmaceut Univ, Guangdong TCM Key Lab Metab Dis, Key Unit Modulating Liver Treat Hyperlipemia, SATCM Level Lab Lipid Metab 3,SATCM, Guangzhou 510006, Guangdong, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2014年 / 28卷 / 23期

基金：

中国国家自然科学基金;

关键词：

Anoectochilus elwesii; triterpene; insulin-resistant human HepG2 cells; SAPONINS;

D O I：

10.1080/14786419.2014.931388

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new triterpene (1), 3-beta-O-olean-11,13 (18)-diene-23,28-dioic acid, together with five known compounds (2-6), was isolated from Anoectochilus elwesii and their structures were elucidated by extensive spectroscopic methods and comparison with the literature data. Compound 1 was the first example of highly oxygenated triterpene obtained from Anoectochilus genus. The isolated compounds were evaluated on insulin-resistant human HepG2 cells for stimulating glucose uptake activity and the new compound displayed highly potent effect on the stimulation of glucose uptake in human HepG2 cells.

引用

页码：2163 / 2168

页数：6

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