Is tumor (R)ejection by the immune system the "5th R" of radiobiology?

被引：56

作者：

Golden, Encouse B. ^{[1
]}

Formenti, Silvia C. ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Radiat Oncol, New York, NY 10012 USA

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 03期

关键词：

abscopal effect; ATP; calreticulin; CTLA4; CXCL16; CXCR6; HMGB1; immunogenic cell death; ionizing irradiation; ipilimumab; NKG2D; radiobiology; RAE-1; IMMUNOTHERAPY; CANCER;

D O I：

10.4161/onci.28133

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Traditional factors of DNA damage and tumor cell kill, described by the "4 R's" of radiobiology (Reassortment, Reoxy-genation, Repair, and Repopulation) fall short in explaining the role of immunity in hosts treated with radiotherapy. We propose a "5th R," (immune-mediated) Rejection, which recognizes the contribution of the immune system to the antineoplastic effects of radiotherapy.

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