Fever, vesicles around the mouth that are characteristic of herpes simplex virus infection, and blurred vision in the right eye developed concurrently in a 62-year-old woman. Intracameral and intravitreal cells were found in the right eye. These lesions did not respond to antibacterial antibiotics, but they resolved after treatment with acyclovir. The serum titers for herpes simplex virus type-1 were elevated. No corneal ulceration or stromal opacity was found. Herpetic uveitis that is not associated with significant corneal disease, as was found in the patient, may be uncommon.