Classical and alternative receptors for SARS-CoV-2 therapeutic strategy

被引：46
作者：
Masre, Siti Fathiah [1 ]
Jufri, Nurul Farhana [1 ]
Ibrahim, Farah Wahida [1 ]
Raub, Sayyidi Hamzi Abdul [2 ]
机构：
[1] Univ Kebangsaan Malaysia, Fac Hlth Sci, Ctr Toxicol & Hlth Risk Studies, Kuala Lumpur 50300, Malaysia
[2] Pantai Hosp Kuala Lumpur, Reference Specialised Lab, Pantai Premier Pathol SDN BHD, Kuala Lumpur, Malaysia
来源：
REVIEWS IN MEDICAL VIROLOGY | 2021年 / 31卷 / 05期
关键词：
ACE2; Covid-19; entry molecule; SARS-CoV-2; TMPRSS2; DIPEPTIDYL-PEPTIDASE-IV; SPIKE PROTEIN; CORONAVIRUS; EXPRESSION; ACE2; CD147; EMMPRIN; TMPRSS2; CELLS; ENTRY;
D O I：
10.1002/rmv.2207
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Understanding the molecules that are essential for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) entry can provide insights into viral infection and dissemination. Recently, it has been identified from several studies that angiotensin-converting enzyme 2 receptor and transmembrane serine protease 2 are the main entry molecules for the SARS-CoV-2, which produced the pandemic of Covid-19. However, additional evidence showed several other viral receptors and cellular proteases that are also important in facilitating viral entry and transmission in the target cells. In this review, we summarized the types of SARS-CoV-2 entry molecules and discussed their crucial roles for virus binding, protein priming and fusion to the cellular membrane important for SARS-CoV-2 infection.
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页码：1 / 9
页数：9
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