Status of non-steroidal anti-inflammatory drugs use and its association with chronic kidney disease: A cross-sectional survey in China

AimNon-steroidal anti-inflammatory drugs (NSAIDs) have been reported to be associated with adverse effects including kidney injury, while relevant studies from developing countries are limited. We aimed to explore the status of NSAIDs use in China, as well as cross-sectional association between NSAIDs intake and presence of chronic kidney disease (CKD). MethodsA national representative sample of 47204 adults in China was used. Prevalence of regular NSAIDs use was reported. Age- and sex- matched controls of NSAIDs users were then selected. The association between NSAIDs use and kidney injury were analyzed using logistic regression. ResultsAltogether 1129 participants reported regular use of NSAIDs, with the adjusted prevalence of 3.6% (95% CI, 3.2%-3.9%). And 76.9% of them (n=868) had taken phenacetin-containing analgesics, with an adjusted prevalence of 3.2% (95% CI, 2.9%-3.5%). After adjusting for potential confounders, long-term NSAIDs intake (48 months) was associated with eGFR< 60mL/min per 1.73m(2), with an OR of 2.36 (95% CI, 1.28-4.37). ConclusionRegular use of NSAIDs, especially phenacetin-containing drugs, is prevalent in China. And long-term NSAIDs intake (48 months) was independently associated with reduced renal function. Summary at a Glance Cross-sectional analyses of NSAID use and the incidence of CKD in a large Chinese population. 3.6% reported regular NSAID intake, of which 76% were taking phenacetin containing analgesics. Long term NSAID use was associated with an OR 2.36 (95%CI 1.28-4.37) of CKD with an eGFR < 60mL/min per 1.73m(2).