From plasmids to protection: A review of DNA vaccines against infectious diseases

被引：81

作者：

Laddy, Dominick J. ^{[1
]}

Weiner, David B. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2006年 / 25卷 / 3-4期

关键词：

DNA vaccine; HIV; influenza;

D O I：

10.1080/08830180600785827

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The field of DNA vaccine development began over 16 years ago with the observation that plasmid DNA could be injected into and expressed in vivo and drive adaptive immune responses. Since then, there has been great interest in developing this technology to create a new generation of vaccines with the ability to elicit both humoral and cellular immune responses from an inherently innocuous injection. However, DNA vaccines have yet to proceed past phase I/II clinical trials in humans - primarily due to a desire to induce more potent immune responses. This review will examine how DNA vaccines function to induce an immune response and how this information might be useful in future vaccine design.

引用

页码：99 / 123

页数：25

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