Application of microreactor technology in process development

被引：171

作者：

Zhang, XN ^{[1
]}

Stefanick, S ^{[1
]}

Villani, FJ ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Chem Dev, Drug Evaluat, Raritan, NJ 08869 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2004年 / 8卷 / 03期

关键词：

D O I：

10.1021/op034193x

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The microreactor technology is an efficient tool for kilogram-scale syntheses in continuous mode and is particularly effective for hazardous reactions that do not allow scale-up in conventional reactors. Applications to several classes of reactions including highly exothermic reactions, high-temperature reactions, reactions With unstable intermediates, and reactions involving hazardous reagents are described herein.

引用

页码：455 / 460

页数：6

共 29 条

[1] Practical use of continuous processing in developing and scaling up laboratory processes [J].

Anderson, NG .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2001, 5 (06) :613-621

[2]

ARCHER N, 2001, Patent No. 6169205

[3] New aza-dipeptide analogues as potent and orally absorbed HIV-1 protease inhibitors:: Candidates for clinical development [J].

Bold, G ;

Fässler, A ;

Capraro, HG ;

Cozens, R ;

Klimkait, T ;

Lazdins, J ;

Mestan, J ;

Poncioni, B ;

Rösel, J ;

Stover, D ;

Tintelnot-Blomley, M ;

Acemoglu, F ;

Beck, W ;

Boss, E ;

Eschbach, M ;

Hürlimann, T ;

Masso, E ;

Roussel, S ;

Ucci-Stoll, K ;

Wyss, D ;

Lang, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (18) :3387-3401

[4] A new multipurpose microreactor for process safety studies [J].

Bou-Diab, L ;

Fierz, H ;

Gwerder, C ;

Suter, G .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2003, 7 (06) :1077-1078

[5]

CLARK J, 2003, ORG PROCESS RES DEV, V7, P533

[6]

EHRFELD W, 2000, MICROREACTOR NEW TEC

[7]

Flick K., 1972, U. S. Patent Appl., Patent No. [US3652589, 3652589]

[8] Continuous-flow generation of anhydrous diazonium species: Monolithic microfluidic reactors for the chemistry of unstable intermediates [J].

Fortt, R ;

Wootton, RCR ;

de Mello, AJ .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2003, 7 (05) :762-768

[9]

GERHARD P, 2003, SYNTHESIS-STUTTGART, P2827

[10] The application of micro reactors to synthetic chemistry [J].

Haswell, SJ ;

Middleton, RJ ;

O'Sullivan, B ;

Skelton, V ;

Watts, P ;

Styring, P .

CHEMICAL COMMUNICATIONS, 2001, (05) :391-398

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