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A COMPARISON OF SONOTHROMBOLYSIS IN AGED CLOTS BETWEEN LOWBOILING-POINT PHASE-CHANGE NANODROPLETS AND MICROBUBBLES OF THE SAME COMPOSITION
被引：40
|作者：
Kim, Jinwook
[1
,2
]
DeRuiter, Ryan M.
[1
,2
]
Goel, Leela
[1
,2
,3
]
Xu, Zhen
[4
]
Jiang, Xiaoning
[1
,2
,3
]
Dayton, Paul A.
[1
,2
]
机构：
[1] Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC 27599 USA
[2] North Carolina State Univ, Chapel Hill, NC USA
[3] North Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC USA
[4] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
基金：
美国国家卫生研究院;
关键词：
Sonothrombolysis;
Nanodroplets;
Microbubbles;
Cavitation;
Clot;
ULTRASOUND-ENHANCED THROMBOLYSIS;
PERFLUOROCARBON DROPLETS;
HISTOTRIPSY;
CAVITATION;
DELIVERY;
D O I：
10.1016/j.ultrasmedbio.2020.07.008
中图分类号：
O42 [声学];
学科分类号：
070206 ;
082403 ;
摘要：
We present enhanced cavitation erosion of blood clots exposed to low-boiling-point (-2 degrees C) perfluorocarbon phase-change nanodroplets and pulsed ultrasound, as well as microbubbles with the same formulation under the same conditions. Given prior success with microbubbles as a sonothrombolysis agent, we considered that perfluorocarbon phase-change nanodroplets could enhance clot disruption further beyond that achieved with microbubbles. It has been hypothesized that owing to their small size and ability to penetrate into a clot, nanodroplets could enhance cavitation inside a blood clot and increase sonothrombolysis efficacy. The thrombolytic effects of lipid-shell-decafluorobutane nanodroplets were evaluated and compared with those of microbubbles with the same formulation, in an aged bovine blood clot flow model. Seven different pulsing schemes, with an acoustic intensity (I-SPTA) range of 0.021-34.8 W/cm(2) were applied in three different therapy scenarios: ultrasound only, ultrasound with microbubbles and ultrasound with nanodroplets (n = 5). Data indicated that pulsing schemes with 0.35 W/cm(2) and 5.22 W/cm(2) produced a significant difference (p < 0.05) in nanodroplet sonothrombolysis performance compared with compositionally identical microbubbles. With these excitation conditions, nanodroplet-mediated treatment achieved a 140% average thrombolysis rate over the microbubble-mediated case. We observed distinctive internal erosion in the middle of bovine clot samples from nanodroplet-mediated ultrasound, whereas the microbubble-mediated case generated surface erosion. This erosion pattern was supported by ultrasound imaging during sonothrombolysis, which revealed that nanodroplets generated cavitation clouds throughout a clot, whereas microbubble cavitation formed larger cavitation clouds only outside a clot sample. (E-mail: padayton@email.unc.edu) (C) 2020 Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.
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页码：3059 / 3068
页数：10
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