Marine Macrolides, a Promising Source of Antitumor Compounds

被引:37
作者
Napolitano, Jose G. [1 ]
Daranas, Antonio H. [1 ,2 ]
Norte, Manuel [1 ]
Fernandez, Jose J. [1 ]
机构
[1] Univ La Laguna, Inst Univ Bioorgan Antonio Gonzalez, San Cristobal la Laguna 38206, Canary Islands, Spain
[2] Univ La Laguna, Dept Ingn Quim & Tecnol Farmaceut, San Cristobal la Laguna 38071, Canary Islands, Spain
关键词
Marine macrolides; antitumor agents; natural products; cytotoxicity; cancer; POTENT CYTOTOXIC MACROLIDE; EUKARYOTIC TRANSLATION INITIATION; MICROTUBULE-STABILIZING MACROLIDE; ENANTIOSELECTIVE TOTAL-SYNTHESIS; NATURAL-PRODUCTS; APLYRONINE-A; SWINHOLIDE-A; ABSOLUTE STEREOCHEMISTRY; BIOACTIVE MACROLIDES; SALICYLIHALAMIDE-A;
D O I
10.2174/187152009787313800
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Marine organisms have attracted scientific community as a rich source of natural products with unusual structural features and remarkable biological activities. Marine macrolides are a prominent class of natural products characterized by a highly oxygenated polyene backbone containing a macrocyclic lactone as a conformational constraint. Many marine macrolides possess outstanding cell growth antiproliferative properties, making them valuable molecular probes for the investigation of biochemical pathways and promising lead compounds for the development of new antitumor chemotherapeutic agents. In the present review we intend to focus on marine macrolides with potent cytotoxic activity that could be exploited in cancer research and therapy, along with those macrolides currently in clinical trials and/or preclinical development.
引用
收藏
页码:122 / 137
页数:16
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