Immune Organs and Immune Cells on a Chip: An Overview of Biomedical Applications

被引：49

作者：

Morsink, Margaretha A. J. ^{[1
,2
,3
]}

Willemen, Niels G. A. ^{[1
,2
]}

Leijten, Jeroen ^{[2
]}

Bansal, Ruchi ^{[3
]}

Shin, Su Ryon ^{[1
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Div Engn Med, Dept Med, Cambridge, MA 02139 USA

[2] Univ Twente, Fac Sci & Technol, Dept Dev BioEngn, Tech Med Ctr, Drienerlolaan 5, NL-7522 NB Enschede, Netherlands

[3] Univ Twente, Fac Sci & Technol, Dept Med Cell BioPhys, Translat Liver Res,Tech Med Ctr, Drienerlolaan 5, NL-7522 NB Enschede, Netherlands

来源：

MICROMACHINES | 2020年 / 11卷 / 09期

基金：

美国国家卫生研究院;

关键词：

immune system; microfluidics; immune cells; organ-on-a-chip; 3D in vitro model; immune system-on-a-chip; HEMATOPOIETIC STEM-CELLS; IN-VITRO; MICROFLUIDIC MODEL; ENDOTHELIAL-CELLS; SYSTEM; INFLAMMATION; RESPONSES; ANTIBODY; CULTURE; BLOOD;

D O I：

10.3390/mi11090849

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Understanding the immune system is of great importance for the development of drugs and the design of medical implants. Traditionally, two-dimensional static cultures have been used to investigate the immune system in vitro, while animal models have been used to study the immune system's function and behavior in vivo. However, these conventional models do not fully emulate the complexity of the human immune system or the human in vivo microenvironment. Consequently, many promising preclinical findings have not been reproduced in human clinical trials. Organ-on-a-chip platforms can provide a solution to bridge this gap by offering human micro-(patho)physiological systems in which the immune system can be studied. This review provides an overview of the existing immune-organs-on-a-chip platforms, with a special emphasis on interorgan communication. In addition, future challenges to develop a comprehensive immune system-on-chip model are discussed.

引用

页数：25

共 122 条

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