Incidence of antipsychotic use in relation to diagnosis of Alzheimer's disease among community-dwelling persons

被引：21

作者：

Koponen, Marjaana ^{[1
]}

Tolppanen, Anna-Maija ^{[2
]}

Taipale, Heidi ^{[1
]}

Tanskanen, Antti ^{[3
,4
]}

Tiihonen, Jari ^{[3
,4
,5
]}

Johnell, Kristina ^{[6
,7
,8
]}

Fastbom, Johan ^{[6
,7
]}

Ahonen, Riitta ^{[1
]}

Hartikainen, Sirpa ^{[1
]}

机构：

[1] Univ Eastern Finland, Sch Pharm, FI-70211 Kuopio, Finland

[2] Univ Eastern Finland, Res Ctr Comparat Effectiveness & Patient Safety R, FI-70211 Kuopio, Finland

[3] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[4] Natl Inst Hlth & Welf, Helsinki, Finland

[5] Univ Eastern Finland, Dept Forens Psychiat, Niuvanniemi Hosp, FI-70211 Kuopio, Finland

[6] Karolinska Inst, Aging Res Ctr, Stockholm, Sweden

[7] Stockholm Univ, S-10691 Stockholm, Sweden

[8] Stockholm Gerontol Res Ctr, Stockholm, Sweden

来源：

BRITISH JOURNAL OF PSYCHIATRY | 2015年 / 207卷 / 05期

关键词：

NEUROPSYCHIATRIC SYMPTOMS; ATYPICAL ANTIPSYCHOTICS; DEMENTIA; RISK; DELIRIUM; METAANALYSIS; MEDICATIONS; ASSOCIATION; PREVALENCE; NATIONWIDE;

D O I：

10.1192/bjp.bp.114.162834

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background Behavioural and psychological symptoms of dementia are frequently treated with antipsychotics. Aims To determine the incidence of antipsychotic use in relation to diagnosis of Alzheimer's disease. Method Cohort of all community-dwellers in Finland diagnosed with Alzheimer's disease in 2005 and matched controls. All antipsychotics dispensed between 1995 and 2009 were extracted from the Finnish National Prescription Register. Results Altogether 1996/6087 (32.8%) persons with Alzheimer's disease initiated antipsychotic use. The incidence of antipsychotic use was fivefold among persons with Alzheimer's disease compared with controls, started to increase 2-3 years before diagnosis and was highest during the first 6 months after diagnosis. Conclusions A distinct increase in antipsychotic initiations occurs in the same time window as Alzheimer's disease diagnosis.

引用

页码：444 / 449

页数：6

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