High efficient and cost-effective screening method for diabetic cardiovascular risk

被引:1
作者
Kajimoto, Tadafumi [1 ]
Sawamura, Mami S. [1 ]
Hayashi, Reiko D. [1 ]
Oya, Takeshi [1 ]
Hirao, Rieko A. [1 ]
Kouhara, Haruhiko [1 ]
机构
[1] Osaka Minami Med Ctr, Natl Hosp Org, Dept Internal Med Endocrinol & Metab, Kawachi Nagano, Osaka 5868521, Japan
关键词
CORONARY-HEART-DISEASE; RHEUMATOID-ARTHRITIS; CAROTID ATHEROSCLEROSIS; ARTERY-DISEASE; AORTIC-ARCH; CALCIFICATION; PREDICTION; ASSOCIATION; MARKERS; STROKE;
D O I
10.1186/1758-5996-6-51
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The vascular complications of outpatients with diabetes at ordinary hospitals vary. Ischemic heart disease is barely predictable after treatment using previously reported therapeutic indices. We developed a simple and noninvasive screening method to evaluate the possibility of ischemic heart disease in patients with diabetes. Methods: Five years of clinical data from 337 outpatients (196 males and 141 females) with diabetes were analyzed. Twenty-three males and 14 females had ischemic heart disease. We examined the possibility of predicting ischemic heart disease after analyzing this population. The analyzed laboratory data included the following: minimum value of right or left ankle-brachial indices (ABI), maximum value of right or left pulse wave velocities (PWV), aortic calcification diagnosed on plain chest radiographs, plaque score (PS), maximum value of intima media thickness at the cervical artery (IMT), electrocardiographic (ECG) ischemic changes (including ST-T changes or abnormal Q waves, which were re-examined by a cardiologist), HbA1c, low-density lipoprotein cholesterol (LDL-C), uric acid (UA), urine albumin, age, sex, disease duration, and body mass index. All data were subjected to multivariate logistic regression analyses. Results: The presence of ECG ischemic changes, aortic calcification, minimum ABI, maximum IMT, LDL-C, and UA were evaluated in multivariate logistic regression analysis with the onset of ischemic heart disease. The receiver operating characteristic curve indicated an area under the curve of 0.879 (0.820 - 0.938; P = 0.00). Conclusions: Ischemic heart disease could be predicted in patients with diabetes using a combination of results from conventional physical and laboratory tests.
引用
收藏
页数:6
相关论文
共 26 条
[1]   Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury [J].
Bouchard, Josee ;
Soroko, Sharon B. ;
Chertow, Glenn M. ;
Himmelfarb, Jonathan ;
Ikizler, T. Alp ;
Paganini, Emil P. ;
Mehta, Ravindra L. .
KIDNEY INTERNATIONAL, 2009, 76 (04) :422-427
[2]   Carotid ultrasound is useful for the cardiovascular risk stratification of patients with rheumatoid arthritis: results of a population-based study [J].
Corrales, Alfonso ;
Gonzalez-Juanatey, Carlos ;
Peiro, Maria E. ;
Blanco, Ricardo ;
Llorca, Javier ;
Gonzalez-Gay, Miguel A. .
ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (04) :722-727
[3]   Cardiovascular risk stratification in rheumatic diseases: carotid ultrasound is more sensitive than Coronary Artery Calcification Score to detect subclinical atherosclerosis in patients with rheumatoid arthritis [J].
Corrales, Alfonso ;
Parra, Jose A. ;
Gonzalez-Juanatey, Carlos ;
Rueda-Gotor, Javier ;
Blanco, Ricardo ;
Llorca, Javier ;
Gonzalez-Gay, Miguel A. .
ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (11) :1764-1770
[4]   SOME FACTORS ASSOCIATED WITH THE DEVELOPMENT OF CORONARY HEART-DISEASE - 6 YEARS FOLLOW-UP EXPERIENCE IN THE FRAMINGHAM-STUDY [J].
DAWBER, TR ;
KANNEL, WB ;
REVOTSKIE, N ;
STOKES, J ;
KAGAN, A ;
GORDON, T .
AMERICAN JOURNAL OF PUBLIC HEALTH AND THE NATIONS HEALTH, 1959, 49 (10) :1349-1356
[5]   Independent Relationship of Osteoprotegerin Concentrations with Endothelial Activation and Carotid Atherosclerosis in Patients with Severe Rheumatoid Arthritis [J].
Dessein, Patrick H. ;
Lopez-Mejias, Raquel ;
Gonzalez-Juanatey, Carlos ;
Genre, Fernanda ;
Miranda-Filloy, Jose A. ;
Llorca, Javier ;
Gonzalez-Gay, Miguel A. .
JOURNAL OF RHEUMATOLOGY, 2014, 41 (03) :429-436
[6]  
Fowkes FGR, 2008, JAMA-J AM MED ASSOC, V300, P197, DOI 10.1001/jama.300.2.197
[7]   Cost-effectiveness of alternative test strategies for the diagnosis of coronary artery disease [J].
Garber, AM ;
Solomon, NA .
ANNALS OF INTERNAL MEDICINE, 1999, 130 (09) :719-+
[8]   EXERCISE-INDUCED ST DEPRESSION IN THE DIAGNOSIS OF CORONARY-ARTERY DISEASE - A META-ANALYSIS [J].
GIANROSSI, R ;
DETRANO, R ;
MULVIHILL, D ;
LEHMANN, K ;
DUBACH, P ;
COLOMBO, A ;
MCARTHUR, D ;
FROELICHER, V .
CIRCULATION, 1989, 80 (01) :87-98
[9]  
Gibbons RJ, 1997, J AM COLL CARDIOL, V30, P260
[10]   Rheumatoid arthritis: A disease associated with accelerated atherogenesis [J].
Gonzalez-Gay, MA ;
Gonzalez-Juanatey, C ;
Martin, J .
SEMINARS IN ARTHRITIS AND RHEUMATISM, 2005, 35 (01) :8-17