Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations

被引：295
作者：
Hausenloy, Derek J. [1 ,2 ,3 ,4 ]
Botker, Hans Erik [5 ]
Engstrom, Thomas [6 ]
Erlinge, David [7 ]
Heusch, Gerd [8 ]
Ibanez, Borja [9 ,10 ]
Kloner, Robert A. [11 ,12 ]
Ovize, Michel [13 ,14 ]
Yellon, Derek M. [3 ,4 ]
Garcia-Dorado, David [15 ]
机构：
[1] Duke NUS Grad Med Sch, Cardiovasc & Metab Disorders Program, 8 Coll Rd, Singapore 169857, Singapore
[2] Natl Heart Ctr Singapore, Natl Heart Res Inst Singapore, Singapore 169609, Singapore
[3] UCL, Hatter Cardiovasc Inst, Inst Cardiovasc Sci, London, England
[4] Univ Coll London Hosp, Biomed Res Ctr, Natl Inst Hlth Res, London W1T 7DN, England
[5] Aarhus Univ Hosp Skejby, Dept Cardiol, DK-8200 Aarhus N, Denmark
[6] Copenhagen Univ Hosp, Dept Cardiol, Rigshosp, Copenhagen, Denmark
[7] Lund Univ, Dept Cardiol, Lund, Sweden
[8] Univ Essen Gesamthsch, Sch Med, Inst Pathophysiol, West German Heart & Vasc Ctr, Essen, Germany
[9] Ctr Nacl Invest Cardiovasc Carlos III CNIC, Madrid, Spain
[10] IIS Fdn Jimenez Diaz Hosp, Madrid, Spain
[11] Huntington Med Res Inst, Pasadena, CA USA
[12] Univ Southern Calif, Keck Sch Med, Dept Med, Div Cardiovasc Med, Los Angeles, CA USA
[13] Hop Louis Pradel, Explorat Fonct Cardiovasc, Lyon, France
[14] Univ Claude Bernard, UMR CarMeN 1060, Lyon, France
[15] Univ Autonoma Barcelona, Vall dHebron Univ Hosp & Res Inst, Dept Cardiol, Pg Vall dHebron 119-129, Barcelona 08035, Spain
来源：
EUROPEAN HEART JOURNAL | 2017年 / 38卷 / 13期
关键词：
PERCUTANEOUS CORONARY INTERVENTION; PERMEABILITY TRANSITION PORE; LEFT-VENTRICULAR FUNCTION; BYPASS GRAFT-SURGERY; LONG-TERM BENEFIT; PROTEIN KINASE-C; ISCHEMIA-REPERFUSION; MICROVASCULAR OBSTRUCTION; CELLULAR BIOLOGY; CYCLOSPORINE-A;
D O I：
10.1093/eurheartj/ehw145
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页码：935 / +
页数：11
相关论文
共 130 条
[61]  
Ibáñez B, 2015, J AM COLL CARDIOL, V65, P1455, DOI 10.1016/j.jacc.2015.02.032
[62]   Effect of Early Metoprolol on Infarct Size in ST-Segment-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention The Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) Trial [J].
Ibanez, Borja ;
Macaya, Carlos ;
Sanchez-Brunete, Vicente ;
Pizarro, Gonzalo ;
Fernandez-Friera, Leticia ;
Mateos, Alonso ;
Fernandez-Ortiz, Antonio ;
Garcia-Ruiz, Jose M. ;
Garcia-Alvarez, Ana ;
Iniguez, Andres ;
Jimenez-Borreguero, Jesus ;
Lopez-Romero, Pedro ;
Fernandez-Jimenez, Rodrigo ;
Goicolea, Javier ;
Ruiz-Mateos, Borja ;
Bastante, Teresa ;
Arias, Mercedes ;
Iglesias-Vazquez, Jose A. ;
Rodriguez, Maite D. ;
Escalera, Noemi ;
Acebal, Carlos ;
Cabrera, Jose A. ;
Valenciano, Juan ;
Perez de Prado, Armando ;
Fernandez-Campos, Maria J. ;
Casado, Isabel ;
Garcia-Rubira, Juan C. ;
Garcia-Prieto, Jaime ;
Sanz-Rosa, David ;
Cuellas, Carlos ;
Hernandez-Antolin, Rosana ;
Albarran, Agustin ;
Fernandez-Vazquez, Felipe ;
de la Torre-Hernandez, Jose M. ;
Pocock, Stuart ;
Sanz, Gines ;
Fuster, Valentin .
CIRCULATION, 2013, 128 (14) :1495-1503
[63]   Inhibition of δ-protein kinase C protects against reperfusion injury of the ischemic heart in vivo [J].
Inagaki, K ;
Chen, L ;
Ikeno, F ;
Lee, FH ;
Imahashi, K ;
Bouley, DM ;
Rezaee, M ;
Yock, PG ;
Murphy, E ;
Mochly-Rosen, D .
CIRCULATION, 2003, 108 (19) :2304-2307
[64]   Activation of cGMP/Protein Kinase G Pathway in Postconditioned Myocardium Depends on Reduced Oxidative Stress and Preserved Endothelial Nitric Oxide Synthase Coupling [J].
Inserte, Javier ;
Hernando, Victor ;
Vilardosa, Ursula ;
Abad, Elena ;
Poncelas-Nozal, Marcos ;
Garcia-Dorado, David .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2013, 2 (01) :e005975
[65]   Contribution of calpains to myocardial ischaemia/reperfusion injury [J].
Inserte, Javier ;
Hernando, Victor ;
Garcia-Dorado, David .
CARDIOVASCULAR RESEARCH, 2012, 96 (01) :23-31
[66]   Randomized Phase 2 Trial of Intracoronary Nitrite During Acute Myocardial Infarction [J].
Jones, Daniel A. ;
Pellaton, Cyril ;
Velmurugan, Shanti ;
Rathod, Krishnaraj Sinha ;
Andiapen, Mervyn ;
Antoniou, Sotiris ;
van Eijl, Sven ;
Webb, Andrew J. ;
Westwood, Mark A. ;
Parmar, Mahesh K. ;
Mathur, Anthony ;
Ahluwalia, Amrita .
CIRCULATION RESEARCH, 2015, 116 (03) :437-+
[67]   Combination therapy with remote ischaemic conditioning and insulin or exenatide enhances infarct size limitation in pigs [J].
Jose Alburquerque-Bejar, Juan ;
Barba, Ignasi ;
Inserte, Javier ;
Miro-Casas, Elisabet ;
Ruiz-Meana, Marisol ;
Poncelas, Marcos ;
Vilardosa, Ursula ;
Valls-Lacalle, Laura ;
Rodriguez-Sinovas, Antonio ;
Garcia-Dorado, David .
CARDIOVASCULAR RESEARCH, 2015, 107 (02) :246-254
[68]   Cyclosporine Does Not Reduce Myocardial Infarct Size in a Porcine Ischemia-Reperfusion Model [J].
Karlsson, Lars O. ;
Zhou, Alex-Xianghua ;
Larsson, Erik ;
Astrom-Olsson, Karin ;
Mansson, Chrichan ;
Akyurek, Levent M. ;
Grip, Lars .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2010, 15 (02) :182-189
[69]   Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury [J].
Kawaguchi, Masanori ;
Takahashi, Masafumi ;
Hata, Takeki ;
Kashima, Yuichiro ;
Usui, Fumitake ;
Morimoto, Hajime ;
Izawa, Atsushi ;
Takahashi, Yasuko ;
Masumoto, Junya ;
Koyama, Jun ;
Hongo, Minoru ;
Noda, Tetsuo ;
Nakayama, Jun ;
Sagara, Junji ;
Taniguchi, Shun'ichiro ;
Ikeda, Uichi .
CIRCULATION, 2011, 123 (06) :594-+
[70]   Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials [J].
Kitakaze, Masafumi ;
Asakura, Masanori ;
Kim, Jiyoong ;
Shintani, Yasunori ;
Asanuma, Hiroshi ;
Hamasaki, Toshimitsu ;
Seguchi, Osamu ;
Myoishi, Masafumi ;
Minamino, Tetsuo ;
Ohara, Takahiro ;
Nagai, Yoshiyuki ;
Nanto, Shinsuke ;
Watanabe, Kouki ;
Fukuzawa, Shigeru ;
Hirayama, Atsushi ;
Nakamura, Natsuki ;
Kimura, Kazuo ;
Fujii, Kenshi ;
Ishihara, Masaharu ;
Saito, Yoshihiko ;
Tomoike, Hitonobu ;
Kitamura, Soichiro .
LANCET, 2007, 370 (9597) :1483-1493
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