RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia

被引:50
作者
Arriortua, Oihane K. [1 ]
Insausti, Maite [1 ,2 ]
Lezama, Luis [1 ,2 ]
Gil de Muro, Izaskun [1 ,2 ]
Garaio, Eneko [3 ]
de la Fuente, Jesus Martinez [4 ,5 ]
Fratila, Raluca M. [4 ,5 ]
Morales, Maria P. [6 ]
Costa, Rocio [6 ]
Eceiza, Maite [7 ]
Sagartzazu-Aizpurua, Maialen [7 ]
Aizpurua, Jesus M. [7 ]
机构
[1] Basque Ctr Mat Applicat &Nanostruct, BC Mat, UPV EHU Sci Pk, Leioa 48940, Spain
[2] Univ Basque Country, Inorgan Chem Dept, Leioa 48940, Spain
[3] Univ Basque Country, Elect & Elect Dept, Leioa 48940, Spain
[4] Univ Zaragoza, Inst Ciencia Mat Aragon, Grp Biofunct Nanoparticles & Surfaces, CSIC, Zaragoza, Spain
[5] GBER BBN, Zaragoza, Spain
[6] ICMM CSIC, Inst Ciencia Mat Madrid, Biomat & Bioinspired Mat Dept, Madrid 28049, Spain
[7] Univ Basque Country, UPV EHU, Jose Mari Korta R&D Ctr, Donostia San Sebastian 20018, Spain
关键词
Magnetite; RGD; EMR; Citotoxicity; Hyperthermia; IRON-OXIDE NANOPARTICLES; AZIDE-ALKYNE CYCLOADDITION; CLICK CHEMISTRY; ABSORPTION RATE; NANOCRYSTALS; DESIGN; COPPER; CARBODIIMIDE; GROWTH; SHAPE;
D O I
10.1016/j.colsurfb.2018.02.031
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
To improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, Fe3O4 nanoparticles have been functionalized with a peptide of the type arginine-glycine-aspartate (RGD) following a "click" chemistry approach. The RGD peptide was linked onto the previously coated nanoparticles in order to target alpha(v)beta(3) integrin receptors over-expressed in angiogenic cancer cells. Different coatings have been analyzed to enhance the biocompatibility of magnetic nanoparticles. Monodispersed and homogeneous magnetite nanoparticles have been synthesized by the seed growth method and have been characterized using X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, transmission electron microscopy and magnetic measurements. The magnetic hyperthermia efficiency of the nanoparticles has also been investigated and cytotoxicity assays have been perfomed for functionalized nanoparticles. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码:315 / 324
页数:10
相关论文
共 61 条
[31]   Cu-free click cycloaddition reactions in chemical biology [J].
Jewett, John C. ;
Bertozzi, Carolyn R. .
CHEMICAL SOCIETY REVIEWS, 2010, 39 (04) :1272-1279
[32]  
Junk M.J.N., 2012, Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy
[33]   Fabrication of Carboxylated Silicon Nitride Sensor Chips for Detection of Antigen-Antibody Reaction Using Microfluidic Reflectometric Interference Spectroscopy [J].
Kurihara, Yoshikazu ;
Takama, Masaaki ;
Sekiya, Tadanobu ;
Yoshihara, Yuka ;
Ooya, Tooru ;
Takeuchi, Toshifumi .
LANGMUIR, 2012, 28 (38) :13609-13615
[34]   Surpassing the Use of Copper in the Click Functionalization of Polymeric Nanostructures: A Strain-Promoted Approach [J].
Lallana, Enrique ;
Fernandez-Megia, Eduardo ;
Riguera, Ricardo .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (16) :5748-+
[35]   Correlating Magneto-Structural Properties to Hyperthermia Performance of Highly Monodisperse Iron Oxide Nanoparticles Prepared by a Seeded-Growth Route [J].
Levy, Michael ;
Quarta, Alessandra ;
Espinosa, Ana ;
Figuerola, Albert ;
Wilhelm, Claire ;
Garcia-Hernandez, Mar ;
Genovese, Alessandro ;
Falqui, Andrea ;
Alloyeau, Damien ;
Buonsanti, Raffaella ;
Davide Cozzoli, Pantaleo ;
Angel Garcia, Miguel ;
Gazeau, Florence ;
Pellegrino, Teresa .
CHEMISTRY OF MATERIALS, 2011, 23 (18) :4170-4180
[36]   Design of an amphiphilic polymer for nanoparticle coating and functionalization [J].
Lin, Cheng-An J. ;
Sperling, Ralph A. ;
Li, Jimmy K. ;
Yang, Ting-Ya ;
Li, Pei-Yun ;
Zanella, Marco ;
Chang, Walter H. ;
Parak, Wolfgang J. .
SMALL, 2008, 4 (03) :334-341
[37]   Innovative magnetic nanoparticle platform for magnetic resonance imaging and magnetic fluid hyperthermia applications [J].
Liu, Xiao Li ;
Fan, Hai Ming .
CURRENT OPINION IN CHEMICAL ENGINEERING, 2014, 4 :38-46
[38]   Magnetite Biomineralization in Magnetospirillum gryphiswaldense: Time-Resolved Magnetic and Structural Studies [J].
Luisa Fdez-Gubieda, M. ;
Muela, Alicia ;
Alonso, Javier ;
Garcia-Prieto, Ana ;
Olivi, Luca ;
Fernandez-Pacheco, Rodrigo ;
Manuel Barandiaran, Jose .
ACS NANO, 2013, 7 (04) :3297-3305
[39]   Preparation and characterization of magnetite nanoparticles coated by amino silane [J].
Ma, M ;
Zhang, Y ;
Yu, W ;
Shen, HY ;
Zhang, HQ ;
Gu, N .
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2003, 212 (2-3) :219-226
[40]   Deviation from Bloch T3/2 law in ferrite nanoparticles [J].
Mandal, K. ;
Mitra, Subarna ;
Kumar, P. Anil .
EUROPHYSICS LETTERS, 2006, 75 (04) :618-623