RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia

被引：50
作者：
Arriortua, Oihane K. [1 ]
Insausti, Maite [1 ,2 ]
Lezama, Luis [1 ,2 ]
Gil de Muro, Izaskun [1 ,2 ]
Garaio, Eneko [3 ]
de la Fuente, Jesus Martinez [4 ,5 ]
Fratila, Raluca M. [4 ,5 ]
Morales, Maria P. [6 ]
Costa, Rocio [6 ]
Eceiza, Maite [7 ]
Sagartzazu-Aizpurua, Maialen [7 ]
Aizpurua, Jesus M. [7 ]
机构：
[1] Basque Ctr Mat Applicat &Nanostruct, BC Mat, UPV EHU Sci Pk, Leioa 48940, Spain
[2] Univ Basque Country, Inorgan Chem Dept, Leioa 48940, Spain
[3] Univ Basque Country, Elect & Elect Dept, Leioa 48940, Spain
[4] Univ Zaragoza, Inst Ciencia Mat Aragon, Grp Biofunct Nanoparticles & Surfaces, CSIC, Zaragoza, Spain
[5] GBER BBN, Zaragoza, Spain
[6] ICMM CSIC, Inst Ciencia Mat Madrid, Biomat & Bioinspired Mat Dept, Madrid 28049, Spain
[7] Univ Basque Country, UPV EHU, Jose Mari Korta R&D Ctr, Donostia San Sebastian 20018, Spain
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2018年 / 165卷
关键词：
Magnetite; RGD; EMR; Citotoxicity; Hyperthermia; IRON-OXIDE NANOPARTICLES; AZIDE-ALKYNE CYCLOADDITION; CLICK CHEMISTRY; ABSORPTION RATE; NANOCRYSTALS; DESIGN; COPPER; CARBODIIMIDE; GROWTH; SHAPE;
D O I：
10.1016/j.colsurfb.2018.02.031
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
To improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, Fe3O4 nanoparticles have been functionalized with a peptide of the type arginine-glycine-aspartate (RGD) following a "click" chemistry approach. The RGD peptide was linked onto the previously coated nanoparticles in order to target alpha(v)beta(3) integrin receptors over-expressed in angiogenic cancer cells. Different coatings have been analyzed to enhance the biocompatibility of magnetic nanoparticles. Monodispersed and homogeneous magnetite nanoparticles have been synthesized by the seed growth method and have been characterized using X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, transmission electron microscopy and magnetic measurements. The magnetic hyperthermia efficiency of the nanoparticles has also been investigated and cytotoxicity assays have been perfomed for functionalized nanoparticles. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：315 / 324
页数：10
相关论文
共 61 条
  • [1] A strain-promoted [3+2] azide-alkyne cycloaddition for covalent modification of blomolecules in living systems
    Agard, NJ
    Prescher, JA
    Bertozzi, CR
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (46) : 15046 - 15047
  • [2] Synthesis and characterization of polyethylene glycol (PEG) coated Fe3O4 nanoparticles by chemical co-precipitation method for biomedical applications
    Anbarasu, M.
    Anandan, M.
    Chinnasamy, E.
    Gopinath, V.
    Balamurugan, K.
    [J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2015, 135 : 536 - 539
  • [3] Amino-functionalized silica magnetite nanoparticles for the simultaneous removal of pollutants from aqueous solution
    Araghi, Samira Hozhabr
    Entezari, Mohammad H.
    [J]. APPLIED SURFACE SCIENCE, 2015, 333 : 68 - 77
  • [4] Cyclic RGD Functionalized Gold Nanoparticles for Tumor Targeting
    Arosio, Daniela
    Manzoni, Leonardo
    Araldi, Elena M. V.
    Scolastico, Carlo
    [J]. BIOCONJUGATE CHEMISTRY, 2011, 22 (04) : 664 - 672
  • [5] Magnetic nanoparticles with bulklike properties (invited)
    Batlle, Xavier
    Perez, N.
    Guardia, P.
    Iglesias, O.
    Labarta, A.
    Bartolome, F.
    Garcia, L. M.
    Bartolome, J.
    Roca, A. G.
    Morales, M. P.
    Serna, C. J.
    [J]. JOURNAL OF APPLIED PHYSICS, 2011, 109 (07)
  • [6] Surface characterisation of dextran-coated iron oxide nanoparticles prepared by laser pyrolysis and coprecipitation
    Bautista, MC
    Bomati-Miguel, O
    Morales, MD
    Serna, CJ
    Veintemillas-Verdaguer, S
    [J]. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2005, 293 (01) : 20 - 27
  • [7] Copper-Free Click Chemistry for Highly Luminescent Quantum Dot Conjugates: Application to in Vivo Metabolic Imaging
    Bernardin, Aude
    Cazet, Aurelie
    Guyon, Laurent
    Delannoy, Philippe
    Vinet, Francoise
    Bonnaffe, David
    Texier, Isabelle
    [J]. BIOCONJUGATE CHEMISTRY, 2010, 21 (04) : 583 - 588
  • [8] Carbodiimide versus Click Chemistry for Nanoparticle Surface Functionalization: A Comparative Study for the Elaboration of Multimodal Superparamagnetic Nanoparticles Targeting αvβ3 Integrins
    Bolley, Julie
    Guenin, Erwann
    Lievre, Nicole
    Lecouvey, Marc
    Soussan, Michael
    Lalatonne, Yoann
    Motte, Laurence
    [J]. LANGMUIR, 2013, 29 (47) : 14639 - 14647
  • [9] Chemically Directed Assembly of Photoactive Metal Oxide Nanoparticle Heterojunctions via the Copper-Catalyzed Azide-Alkyne Cycloaddition "Click" Reaction
    Cardiel, Allison C.
    Benson, Michelle C.
    Bishop, Lee M.
    Louis, Kacie M.
    Yeager, Joseph C.
    Tan, Yizheng
    Hamers, Robert J.
    [J]. ACS NANO, 2012, 6 (01) : 310 - 318
  • [10] Fe3O4 nanoparticles prepared by the seeded-growth route for hyperthermia: electron magnetic resonance as a key tool to evaluate size distribution in magnetic nanoparticles
    Castellanos-Rubio, Idoia
    Insausti, Maite
    Garaio, Eneko
    de Muro, Izaskun Gil
    Plazaola, Fernando
    Rojo, Teofilo
    Lezama, Luis
    [J]. NANOSCALE, 2014, 6 (13) : 7542 - 7552
1234567