Tandem oxidative radical decarboxylation-β-iodination of amino acids.: Application to the synthesis of chiral 2,3-disubstituted pyrrolidines

被引：30

作者：

Boto, A ^{[1
]}

Hernández, R ^{[1
]}

Suárez, E ^{[1
]}

机构：

[1] CSIC, Inst Prod Nat & Agrobiol, Tenerife 38206, Spain

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 14期

关键词：

amino acids; radical decarboxylation; halogenation; nitrogen heterocycles; metathesis;

D O I：

10.1016/S0040-4039(00)00188-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient procedure for the tandem decarboxylation-halogenation of alpha-amino acids is reported. The iodine is introduced at previously unfunctionalized positions, in good yields. The methodology has been used for the diastereoselective synthesis of 2,3-disubstituted pyrrolidines. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2495 / 2498

页数：4

共 9 条

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[7] Diastereo- and enantioselective synthesis of 2-substituted 1-aminocyclopropane-1-carboxylic acids. Application to the synthesis of protected 2,3-methiano analogs of ornithine and glutamic acid
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[9] Lewis acid activation of chiral 2-trifluoromethyl-1,3-oxazolidines.: Application to the stereoselective synthesis of trifluoromethylated amines, α- and β-amino acids
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