The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans

被引：164
作者：
Wolf, S. S. [1 ]
机构：
[1] Bayer Schering Pharma AG, Global Drug Discovery, TRG Womens Healthcare, D-13353 Berlin, Germany
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 13期
关键词：
Protein arginine methyltransferase; Post-translational modification; Gene family; Transcriptional regulation; Chromatin; N-METHYLTRANSFERASE; SUBSTRATE-SPECIFICITY; GENE-EXPRESSION; TRANSCRIPTIONAL ACTIVATION; COVALENT MODIFICATIONS; HISTONE METHYLATION; RECEPTOR FUNCTION; OTITIS-MEDIA; IN-VITRO; CARM1;
D O I：
10.1007/s00018-009-0010-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Information about the family of protein arginine methyltransferases (PRMTs) has been growing rapidly over the last few years and the emerging role of arginine methylation involved in cellular processes like signaling, RNA processing, gene transcription, and cellular transport function has been investigated. To date, 11 PRMTs gene transcripts have been identified in humans. Almost all PRMTs have been shown to have enzymatic activity and to catalyze arginine methylation. This review will summarize the overall function of human PRMTs and include novel highlights on each family member.
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收藏
页码：2109 / 2121
页数：13
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