NHC catalysed trimethylsilylation of terminal alkynes and indoles with Ruppert's reagent under solvent free conditions

被引：24

作者：

Arde, Panjab ^{[1
]}

Reddy, Virsinha ^{[1
]}

Anand, Ramasamy Vijaya ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res, Dept Chem Sci, Mohali 140306, Punjab, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 91期

关键词：

N-HETEROCYCLIC CARBENE; GROUP-TRANSFER POLYMERIZATION; CROSS-COUPLING REACTIONS; NUCLEOPHILIC TRIFLUOROMETHYLATION; DEHYDROGENATIVE SILYLATION; ORGANOSILICON COMPOUNDS; CARBONYL-COMPOUNDS; (METH)ACRYLIC MONOMERS; PALLADIUM CATALYST; BORONIC ACIDS;

D O I：

10.1039/c4ra08727e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An organo-catalytic protocol for the trimethylsilylation of terminal alkynes employing Ruppert's reagent (CF3SiMe3) as a trimethylsilyl source has been developed under solvent and fluoride free conditions. This method was found to be very effective as a variety of terminal alkynes bearing aliphatic or aromatic substituents underwent smooth transformation to their corresponding silylated products in excellent yields within a few minutes using N-heterocyclic carbene as an organo-catalyst. This methodology was also applied to the chemo-specific N-silylation of indoles.

引用

页码：49775 / 49779

页数：5

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