Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability

被引：127
作者：
Curzon, G [1 ]
Gibson, EL [1 ]
Oluyomi, AO [1 ]
机构：
[1] UCL, SCH MED, DEPT EPIDEMIOL & PUBL HLTH, LONDON WC1E 6BT, ENGLAND
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 1997年 / 18卷 / 01期
关键词：
D O I：
10.1016/S0165-6147(96)01003-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The widely prescribed appetite suppressants D-fenfluramine and fluoxetine not only decrease feeding and body weight but also increase extracellular brain 5-HT. As central injection of 5-HT also decreases feeding, the drugs are often thought to require an increase of 5-HT at receptors in order to exert their hypophagic effect. However, much evidence now suggests that D-fenfluramine and its metabolite D-norfenfluramine can cause hypophagia by acting directly at unspecified 5-HT receptors and at 5-HT2C receptors, respectively, while fluoxetine may act independently of 5-HT receptors. These hypophagias may involve interference with the hyperphagic action of neuropeptide Y.
引用
收藏
页码：21 / 25
页数：5
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