The tobacco mosaic virus resistance gene, N

被引:69
作者
Marathe, R [1 ]
Anandalakshmi, R [1 ]
Liu, YL [1 ]
Dinesh-Kumar, SP [1 ]
机构
[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
关键词
D O I
10.1046/j.1364-3703.2002.00110.x
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
In this mini review we discuss recent advances in the understanding of the N gene-mediated resistance to tobacco mosaic virus (TMV). The tobacco N gene belongs to toll-interleukin-1 receptor homology/nucleotide binding/leucine rich repeat (TIR-NB-LRR) class of resistance genes. it encodes two transcripts, N-S and N-L, by alternative splicing, both of which are required to confer resistance to TMV. The structure-function analysis of the N gene indicates that the TIR, NB and LRR domains are indispensable for its function. The N gene response is elicited by the C-terminal helicase domain of the 126 kDa TMV replicase protein. Tobacco N gene can also confer resistance to TMV in heterologous plants like tomato and Nicotiana benthamiana. Recent studies on N-mediated signalling suggest that EDS1, Rar1 and NPR1 genes play an important role in TMV resistance. Finally, we discuss current status of the N-mediated signal transduction and speculate directions for future work to understand N-TMV interaction.
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收藏
页码:167 / 172
页数:6
相关论文
共 47 条
[1]   Different requirements for EDS1 and NDR1 by disease resistance genes define at least two R gene-mediated signaling pathways in Arabidopsis [J].
Aarts, N ;
Metz, M ;
Holub, E ;
Staskawicz, BJ ;
Daniels, MJ ;
Parker, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :10306-10311
[2]   Tobacco mosaic virus helicase domain induces necrosis in N gene-carrying tobacco in the absence of virus replication [J].
Abbink, TEM ;
Tjernberg, PA ;
Bol, JF ;
Linthorst, HJM .
MOLECULAR PLANT-MICROBE INTERACTIONS, 1998, 11 (12) :1242-1246
[3]  
ALLARD HA, 1914, USDA B, V40
[4]   The domains of death: evolution of the apoptosis machinery [J].
Aravind, L ;
Dixit, VM ;
Koonin, EV .
TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (02) :47-53
[5]   Signaling in plant-microbe interactions [J].
Baker, B ;
Zambryski, P ;
Staskawicz, B ;
DineshKumar, SP .
SCIENCE, 1997, 276 (5313) :726-733
[6]   Fast forward genetics based on virus-induced gene silencing [J].
Baulcombe, DC .
CURRENT OPINION IN PLANT BIOLOGY, 1999, 2 (02) :109-113
[7]  
Beijerinck M. W., 1898, Verhandelingen der Koninklijke Nederlandsche Akademie van Wetenschappen. Afdeeling Natuurkunde, V5, P3
[8]   The Rx gene from potato controls separate virus resistance and cell death responses [J].
Bendahmane, A ;
Kanyuka, K ;
Baulcombe, DC .
PLANT CELL, 1999, 11 (05) :781-791
[9]   The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats [J].
Cao, H ;
Glazebrook, J ;
Clarke, JD ;
Volko, S ;
Dong, XN .
CELL, 1997, 88 (01) :57-63
[10]   Isolation and characterization of two pathogen- and salicylic acid-induced genes encoding WRKY DNA-binding proteins from tobacco [J].
Chen, CH ;
Chen, ZX .
PLANT MOLECULAR BIOLOGY, 2000, 42 (02) :387-396