Autoimmune Movement Disorders: a Clinical and Laboratory Approach

被引：22

作者：

Honorat, Josephe Archie ^{[1
]}

McKeon, Andrew ^{[1
,2
,3
]}

机构：

[1] Mayo Clin, Coll Med, Dept Lab Med & Pathol, Rochester, MN 55902 USA

[2] Mayo Clin, Coll Med, Dept Neurol, Rochester, MN USA

[3] Mayo Clin, Neuroimmunol Lab, Hilton 3-78,200 1st ST SW, Rochester, MN 55905 USA

来源：

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2017年 / 17卷 / 01期

关键词：

Autoimmunity; Movement disorders; Paraneoplastic; Neuronal autoantibodies; Immunotherapy; STIFF-PERSON SYNDROME; NMDA-RECEPTOR ENCEPHALITIS; OPSOCLONUS-MYOCLONUS SYNDROME; PURKINJE-CELL ANTIBODIES; MEDUSA-HEAD ATAXIA; NEURONAL SURFACE-ANTIGENS; SLEEP BEHAVIOR DISORDER; CASE SERIES; EXPANDING SPECTRUM; PROGRESSIVE ENCEPHALOMYELITIS;

D O I：

10.1007/s11910-017-0709-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Autoimmune movement disorders are caused by an aberrant immune response to neural self-antigens. These disorders may be paraneoplastic, parainfectious, or (most commonly) idiopathic. The neurological presentations are diverse, and sometimes multifocal. Movement disorders can occur as part of the spectrum with phenotypes including chorea, myoclonus, ataxia, CNS hyperexcitability (including stiff-person syndrome), dystonia, and parkinsonism. Symptoms are subacute in onset and may have a fluctuating course. The best characterized disorders are unified by neural autoantibodies identified in serum or cerebrospinal fluid. The antibody specificity may predict the association with cancer and the response to immunotherapy. In this article, we review autoimmune-mediated movement disorders, associated cancers, diagnosis, and treatment.

引用

页数：11

共 104 条

[51] Immunomodulated parkinsonism as a presenting symptom of LGI1 antibody encephalitis [J].

Kurtis, Monica M. ;

Toledano, Rafael ;

Garcia-Morales, Irene ;

Gil-Nagel, Antonio .

PARKINSONISM & RELATED DISORDERS, 2015, 21 (10) :1286-1287

[52] Encephalitis and antibodies to synaptic and neuronal cell surface proteins [J].

Lancaster, Eric ;

Martinez-Hernandez, Eugenia ;

Dalmau, Josep .

NEUROLOGY, 2011, 77 (02) :179-189

[53] CSF herpes virus and autoantibody profiles in the evaluation of encephalitis [J].

Linnoila, Jenny J. ;

Binnicker, Matthew J. ;

Majed, Masoud ;

Klein, Christopher J. ;

McKeon, Andrew .

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2016, 3 (04)

[54] Metabotropic glutamate receptor type 1 autoimmunity Clinical features and treatment outcomes [J].

Lopez-Chiriboga, A. Sebastian ;

Komorowski, Lars ;

Kuempfel, Tania ;

Probst, Christian ;

Hinson, Shannon R. ;

Pittock, Sean J. ;

McKeon, Andrew .

NEUROLOGY, 2016, 86 (11) :1009-1013

[55] Pregnancy in patients with Sydenham's Chorea [J].

Maia, Debora P. ;

Fonseca, Patricia G. ;

Camargos, Sarah T. ;

Pfannes, Claudia ;

Cunningham, Mauro C. ;

Cardoso, Francisco .

PARKINSONISM & RELATED DISORDERS, 2012, 18 (05) :458-461

[56] Clinical utility of testing AQP4-IgG in CSF Guidance for physicians [J].

Majed, Masoud ;

Fryer, James P. ;

McKeon, Andrew ;

Lennon, Vanda A. ;

Pittock, Sean J. .

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2016, 3 (03)

[57] In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction [J].

Manto, Mario ;

Dalmau, Josep ;

Didelot, Adrien ;

Rogemond, Veronique ;

Honnorat, Jerome .

ORPHANET JOURNAL OF RARE DISEASES, 2010, 5

[58] Opsoclonus-myoclonus-ataxia syndrome with autoantibodies to glutamic acid decarboxylase [J].

Markakis, Ioannis ;

Alexiou, Eleni ;

Xifaras, Michael ;

Gekas, Georgios ;

Rombos, Antonios .

CLINICAL NEUROLOGY AND NEUROSURGERY, 2008, 110 (06) :619-621

[59] Clinical and Immunologic Investigations in Patients With Stiff-Person Spectrum Disorder [J].

Martinez-Hernandez, Eugenia ;

Arino, Helena ;

McKeon, Andrew ;

Iizuka, Takahiro ;

Titulaer, Maarten J. ;

Simabukuro, Mateus M. ;

Lancaster, Eric ;

Petit-Pedrol, Mar ;

Planaguma, Jesus ;

Blanco, Yolanda ;

Harvey, Robert J. ;

Saiz, Albert ;

Graus, Francesc ;

Dalmau, Josep .

JAMA NEUROLOGY, 2016, 73 (06) :714-720

[60] Severe hypokinesis caused by paraneoplastic anti-Ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes [J].

Matsumoto, Lumine ;

Yamamoto, Tomotaka ;

Higashihara, Maria ;

Sugimoto, Lzurni ;

Kowa, Hisatorno ;

Shibahara, Junji ;

Nakamura, Koichiro ;

Shimizu, Jun ;

Ugawa, Yoshikazu ;

Goto, Jun ;

Dalmau, Josep ;

Tsuji, Shoji .

MOVEMENT DISORDERS, 2007, 22 (05) :728-731

← 1 2 3 4 5 6 7 8 9 10 →