Clinical manifestations and treatment of antisynthetase syndrome

被引：71

作者：

Marco, Joanna L. ^{[1
]}

Collins, Bridget F. ^{[2
]}

机构：

[1] Univ Washington, Dept Med, Div Rheumatol, 1959 NE Pacific St,Box 356428, Seattle, WA 98195 USA

[2] Univ Washington, Div Pulm Crit Care & Sleep Med, Dept Med, 1959 NE Pacific St,Box 356166, Seattle, WA 98195 USA

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2020年 / 34卷 / 04期

关键词：

Antisynthetase syndrome; Antisynthetase antibody; Anti-Jo-1; Interstitial lung disease; Arthritis; Idiopathic inflammatory myopathy; Mechanic's hands; INTERSTITIAL LUNG-DISEASE; ANTI-SYNTHETASE SYNDROME; IDIOPATHIC INFLAMMATORY MYOPATHIES; ANTI-JO-1; ANTIBODIES; ADULT POLYMYOSITIS; RITUXIMAB; COHORT; TERM; ARTHRITIS; PROFILES;

D O I：

10.1016/j.berh.2020.101503

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antisynthetase syndrome (ASyS) is an autoimmune disease clinically manifested most often by interstitial lung disease, myositis, and arthritis. Raynaud's syndrome, fever, and rashes are also commonly seen. This syndrome is characterized by the highly specific presence of antibodies against various aminoacyl transfer RNA synthetases, including Jo-1 and others. In this chapter, we provide an overview of ASyS, including pathogenesis, common clinical manifestations, and treatment strategies. We discuss the spectrum of disease seen with specific antisynthetase antibodies and examine the differences in phenotype between patients with different antisynthetase antibodies. We outline common treatment strategies, which should generally target the most severe and life- or organ-threatening disease manifestations. Finally, we discuss short- and long-term prognosis in ASyS. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：18

共 106 条

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