Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets

被引:31
作者
Bazzano, M. V. [1 ]
Torelli, C. [2 ]
Pustovrh, M. C. [3 ]
Paz, D. A. [1 ,2 ]
Elia, E. M. [1 ]
机构
[1] Inst Fisiol Biol Mol & Neurociencias IFIBYNE CONI, Lab Biol Desarrollo, Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Biodiversidad & Biol Expt, Buenos Aires, DF, Argentina
[3] Univ Valle, Fac Salud, Escuela Ciencias Basicas, Dept Morfol, Cali, Colombia
关键词
anti-Mullerian hormone; fertility; follicular cyst; folliculogenesis; INSULIN-RESISTANCE; GROWTH-FACTOR; HIGH-FAT; PROSTAGLANDIN E-2; FOLLICULAR-FLUID; BODY-SIZE; IN-VITRO; ESTROGEN; INFLAMMATION; RECEPTOR;
D O I
10.1016/j.rbmo.2015.08.004
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Obesity constitutes a health problem of increasing worldwide prevalence. Among the health detriments caused by obesity, reproduction is disrupted. However, the mechanisms involved in this disruption are not fully understood. Animals fed a cafeteria diet constitute the model for the study of obesity that most closely reflects Western diet habits. The aims of this study were to evaluate whether a cafeteria diet affects ovarian function and to contribute to the understanding of the mechanisms involved. For that purpose, 22-day-old female Wistar rats were fed ad libitum with a standard diet (control group; n = 20) or cafeteria diet (CAF group; n = 20). The cafeteria diet induced obesity and hyperglycaemia, without altering serum triglycerides, cholesterol or C-reactive protein concentrations. This diet also altered ovarian function: the rats showed prolonged dioestrous phases, decreased serum oestradiol concentrations and increased number of antral atretic follicles. Moreover, follicular cysts were detected in the CAF group, concomitantly with a decrease in the number of anti-Mullerian hormone immunoreactive pre-antral follicles and COX-2-positive antral and pre-ovulatory follicles. The authors conclude that a cafeteria diet reduces ovarian reserve, induces the presence of follicular cysts and disturbs the ovulatory process, leading to the delayed pregnancy observed in these animals. (C) 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights
引用
收藏
页码:655 / 667
页数:13
相关论文
共 71 条
[1]  
Aghadavod Esmat, 2015, Adv Biomed Res, V4, P76, DOI 10.4103/2277-9175.153903
[2]   Glucose intolerance associated with early-life exposure to maternal cafeteria feeding is dependent upon post-weaning diet [J].
Akyol, Asli ;
McMullen, Sarah ;
Langley-Evans, Simon C. .
BRITISH JOURNAL OF NUTRITION, 2012, 107 (07) :964-978
[3]   Obesity induced by cafeteria feeding and pregnancy outcome in the rat [J].
Akyol, Asli ;
Langley-Evans, Simon C. ;
McMullen, Sarah .
BRITISH JOURNAL OF NUTRITION, 2009, 102 (11) :1601-1610
[4]  
ALGIRE JE, 1992, CAN J VET RES, V56, P67
[5]   Dietary fatty acids modulate liver mitochondrial cardiolipin content and its fatty acid composition in rats with non alcoholic fatty liver disease [J].
Aoun, Manar ;
Fouret, Gilles ;
Michel, Francoise ;
Bonafos, Beatrice ;
Ramos, Jeanne ;
Cristol, Jean-Paul ;
Carbonneau, Marie-Annette ;
Coudray, Charles ;
Feillet-Coudray, Christine .
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 2012, 44 (04) :439-452
[6]   HIGH-EFFICIENCY OF ENERGY-UTILIZATION IN CAFETERIA-FED AND FORCE-FED RATS KEPT AT 29-DEGREES [J].
BARR, HG ;
MCCRACKEN, KJ .
BRITISH JOURNAL OF NUTRITION, 1984, 51 (03) :379-387
[7]   Daily treatment with α-naphthoflavone enhances follicular growth and ovulation rate in the rat [J].
Barreiro, Karina A. ;
Di Yorio, Maria P. ;
Artillo-Guida, Romina D. ;
Paz, Dante A. ;
Faletti, Alicia G. .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2011, 252 (01) :11-17
[8]   Delay of ovulation by meloxicam in healthy cycling volunteers: A placebo-controlled, double-blind, crossover study [J].
Bata, M. S. ;
Al-Ramahi, M. ;
Salhab, A. S. ;
Gharaibeh, M. N. ;
Schwartz, Jill .
JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 46 (08) :925-932
[9]   Maternal Undernutrition Significantly Impacts Ovarian Follicle Number and Increases Ovarian Oxidative Stress in Adult Rat Offspring [J].
Bernal, Angelica B. ;
Vickers, Mark H. ;
Hampton, Mark B. ;
Poynton, Rebecca A. ;
Sloboda, Deborah M. .
PLOS ONE, 2010, 5 (12)
[10]   ESTROGENS INHIBIT AND ANDROGENS ENHANCE OVARIAN GRANULOSA-CELL APOPTOSIS [J].
BILLIG, H ;
FURUTA, I ;
HSUEH, AJW .
ENDOCRINOLOGY, 1993, 133 (05) :2204-2212