B7-H4 Expression is Associated with Cancer Progression and Predicts Patient Survival in Human Thyroid Cancer

被引：25
作者：
Zhu, Jian [1 ]
Chu, Bing-Feng [1 ]
Yang, Yi-Peng [1 ]
Zhang, Sheng-Lai [1 ]
Zhuang, Ming [1 ]
Lu, Wen-Jie [1 ]
Liu, Ying-Bin [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Dept Gen Surg, Xinhua Hosp, Shanghai 200030, Peoples R China
来源：
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2013年 / 14卷 / 05期
关键词：
Thyroid cancer; B7-H4; progression; prognosis; tumor infiltrating lymphocytes; B7; FAMILY-MEMBER; CELL; MOLECULE;
D O I：
10.7314/APJCP.2013.14.5.3011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: This study aimed to investigate the expression of B7-H4 in human thyroid cancer and determine any association with patient clinicopathological parameters and survival. Methods: B7-H4 expression in 64 clinical thyroid cancer specimens was assessed with immunohistochemistry. Moreover, B7-H4 mRNA expression in 10 fresh resected specimens were evaluated by the reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemical staining of CD3 was performed to assess the number of tumor infiltrating T lymphocytes (TILs) in thyroid cancers. Results: Positive B7-H4 immunohistochemical staining was observed in 61 out of 64 (95.3%) specimens of thyroid cancer tissues. Significantly more B7-H4 mRNA copies were found in thyroid cancer tissue than that adjacent normal tissue. Moreover, B7-H4 expression in human thyroid cancer tissues was significantly correlated with patient TNM stages and extrathyroidal extension (P<0.05), being inversely correlated with the number of TILs (P<0.05). The overall survival rate of the patients with higher B7-H4 expression was significantly worse than that of the patients with lower B7-H4 expression. Conclusions: This present study suggests that high B7-H4 expression is associated with cancer progression, reduced tumor immunosurveillance and worse patient outcomes in human thyroid cancer.
引用
收藏
页码：3011 / 3015
页数：5
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